Electrospray Ionization Tandem Mass Spectrometry of the Two Main Antimalarial Drugs: Artemether and Lumefantrine

dc.creatordos Santos, VG
dc.creatorAlves, RJ
dc.creatorEberlin, MN
dc.creatorPianetti, GA
dc.creatorCesar, IC
dc.date2012
dc.dateJAN
dc.date2014-07-30T17:19:17Z
dc.date2015-11-26T16:51:22Z
dc.date2014-07-30T17:19:17Z
dc.date2015-11-26T16:51:22Z
dc.date.accessioned2018-03-28T23:38:10Z
dc.date.available2018-03-28T23:38:10Z
dc.identifierJournal Of The Brazilian Chemical Society. Soc Brasileira Quimica, v. 23, n. 1, n. 65, n. U395, 2012.
dc.identifier0103-5053
dc.identifierWOS:000300061300011
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/64624
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/64624
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1275970
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionElectrospray ionization in the positive ion mode and high resolution and high accuracy tandem mass spectrometry performed in a hybrid quadrupole time-of-flight mass spectrometer were used to investigate the dissociation chemistry of the intact molecules of two most widely used antimalarial drugs: artemether and lumefantrine. The dissociation pathways of their cationized and protonated forms were rationalized based on high accuracy mass measurements and isotopic distributions. The obtained results should benefit LC-MS/MS monitoring and quantitation by mass spectrometry of the artemether and lumefantrine molecules, as well as of new derivatives or other structurally related antimalarial drugs.
dc.description23
dc.description1
dc.description65
dc.descriptionU395
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherSoc Brasileira Quimica
dc.publisherSao Paulo
dc.publisherBrasil
dc.relationJournal Of The Brazilian Chemical Society
dc.relationJ. Braz. Chem. Soc.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectartemether
dc.subjectlumefantrine
dc.subjection dissociation
dc.subjecttandem mass spectrometry
dc.subjectESI-MS/MS
dc.subjectPerformance Liquid-chromatography
dc.subjectHuman Plasma
dc.subjectMetabolite Dihydroartemisinin
dc.subjectUltraviolet Detection
dc.subjectMajor Metabolite
dc.subjectBlood-plasma
dc.subjectArtemisinin
dc.subjectPharmacokinetics
dc.subjectBenflumetol
dc.subjectCombination
dc.titleElectrospray Ionization Tandem Mass Spectrometry of the Two Main Antimalarial Drugs: Artemether and Lumefantrine
dc.typeArtículos de revistas


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