Artículos de revistas
On cytoadhesion of Plasmodium vivax: raison d'etre?
Registro en:
Memorias Do Instituto Oswaldo Cruz. Fundaco Oswaldo Cruz, v. 106, n. 79, n. 84, 2011.
0074-0276
WOS:000294440600010
Autor
Costa, FTM
Lopes, SCP
Ferrer, M
Leite, JA
Martin-Jaular, L
Bernabeu, M
Nogueira, PA
Mourao, MPG
Fernandez-Becerra, C
Lacerda, MVG
del Portillo, H
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) It is generally accepted that Plasmodium vivax, the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs. Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively associated with P. vivax and that P. vivax-infected reticulocytes are able to cytoadhere in vitro to different endothelial cells and placental cryosections. Here, we review the scarce and preliminary data on cytoadherence in P. vivax, reinforcing the importance of this phenomenon in this species and highlighting the avenues that it opens for our understanding of the pathology of this neglected human malaria parasite. 106 1 79 84 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) CELLEX Foundation MICINN Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)