Anti-leishmanial activity of neolignans from Virola species and synthetic analogues

dc.creatorBarata, LES
dc.creatorSantos, LS
dc.creatorFerri, PH
dc.creatorPhillipson, JD
dc.creatorPaine, A
dc.creatorCroft, SL
dc.date2000
dc.dateNOV
dc.date2014-12-02T16:31:07Z
dc.date2015-11-26T16:45:48Z
dc.date2014-12-02T16:31:07Z
dc.date2015-11-26T16:45:48Z
dc.date.accessioned2018-03-28T23:31:28Z
dc.date.available2018-03-28T23:31:28Z
dc.identifierPhytochemistry. Pergamon-elsevier Science Ltd, v. 55, n. 6, n. 589, n. 595, 2000.
dc.identifier0031-9422
dc.identifierWOS:000165755300013
dc.identifier10.1016/S0031-9422(00)00240-5
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77808
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/77808
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77808
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1274331
dc.descriptionSurinamensin, a neolignan isolated from Virola surinamensis, 3,4,5-trimethoxy-8-[2',6'-dimethoxy-4'-(E)-prophenylphenoxy]phenylpropane, a neolignan isolated from Virola pavonis, and 25 of its synthetic analogues or correlated substances with ether linkages and their corresponding C-8 sulphur and nitrogen analogues, were tested for activity against Leishmania donovani amastigotes and promastigotes in vitro. Some were active against L. donovani promastigotes at 30 muM but inactive against intracellular amastigotes. The natural neolignan from V. pavonis was active against promastigotes at 100 muM. The highest selective activity was found in those compounds with sulphur bridges. The beta -ketosulfide (3,4-dimethoxy)-8-(4'-methylthiophenoxy) produced 42% inhibition of L. donovani amastigotes in the liver of BALB/c mice at 100 mg/kg given once daily for five consecutive days (P > 0.05). (C) 2000 Elsevier Science Ltd. All rights reserved.
dc.description55
dc.description6
dc.description589
dc.description595
dc.languageen
dc.publisherPergamon-elsevier Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationPhytochemistry
dc.relationPhytochemistry
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectVirola surinamensis
dc.subjectVirola pavonis
dc.subjectMyristicaceae
dc.subjectLeishmania donovani
dc.subjectbeta-ketoethers
dc.subjectbeta-ketosulfides
dc.subjectbeta-ketoamines
dc.subjectneolignans
dc.subjectanti-leishmanial activity
dc.subjectAntileishmanial Activity
dc.subjectNatural-products
dc.subjectDonovani
dc.subjectAmazonensis
dc.subjectFight
dc.subjectDrugs
dc.titleAnti-leishmanial activity of neolignans from Virola species and synthetic analogues
dc.typeArtículos de revistas


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