Artículos de revistas
Prevalence of the prothrombin gene variant 20210 G -> A among patients with myocardial infarction
Registro en:
Cardiovascular Research. Elsevier Science Bv, v. 37, n. 1, n. 42, n. 45, 1998.
0008-6363
WOS:000072071600008
10.1016/S0008-6363(97)00211-3
Autor
Arruda, VR
Siquiera, LH
Chiaparini, LC
Coelho, OR
Mansur, AP
Ramires, A
Annichino-Bizzacchi, JM
Institución
Resumen
Objective: The aim of this study was to determine the prevalence of the prothrombin variant allele 20210A among survivors of myocardial infarction Background: The prothrombin gene variant has been identified as a novel genetic risk factor for venous thrombosis. However, the risk of developing arterial thrombosis as a result of the presence of this mutated allele is unknown. Methods: The G --> A transition at position 20210 of the 3'-untranslated region was determined in 220 survivors of myocardial infarction and in 295 individuals from the general population. Results: The prevalence of heterozygotes for the prothrombin mutated allele was 3% among patients with myocardial infarction and 0.7% in the general population (P = 0.03). No age-related difference in the prevalence of the mutated allele was observed. However, for individuals over 45 years old the prevalence among females was higher than among males (5% vs. 0%). Conclusion: These data suggest that being heterozygote for the allele variant 20210A of the prothrombin gene could be a genetic risk factor for developing myocardial infarction. (C) 1998 Elsevier Science B.V. 37 1 42 45