Artículos de revistas
Faster thrombin generation in women with polycystic ovary syndrome compared with healthy controls matched for age and body mass index
Registro en:
Fertility And Sterility. Elsevier Science Inc, v. 99, n. 6, n. 1786, n. 1790, 2013.
0015-0282
WOS:000318612400050
10.1016/j.fertnstert.2013.01.105
Autor
de Mendonca-Louzeiro, MRMF
Annichino-Bizzacchi, JM
Magna, LA
Quaino, SKP
Benetti-Pinto, CL
Institución
Resumen
Objective: To evaluate hemostatic markers in women with polycystic ovary syndrome (PCOS) compared with healthy controls matched for age and body mass index. Design: Cross-sectional study. Setting: Tertiary teaching hospital. Patient(s): Forty-five women with PCOS and 45 controls paired for age (+/- 2 years) and body mass index (+/- 2 kg/m(2)). Intervention(s): Clinical evaluation and venipuncture. Main Outcome Measure(s): Thrombin activatable fibrinolysis inhibitor, D-dimer, plasminogen activator inhibitor-1, and the thrombin generation test. Result(s): Thrombin generation lag-time was significantly shorter in women with PCOS compared with controls. The other hemostatic parameters were similar in both groups. Conclusion(s): Thrombin generation is faster in young and overweight women with PCOS, suggesting a greater risk of hypercoagulability. (c) 2013 by American Society for Reproductive Medicine. 99 6 1786 1790 Sao Paulo State Foundation [2010/11707-0] Sao Paulo State Foundation [2010/11707-0]