Myelopoietic response in tumour-bearing mice by an aggregated polymer isolated from Aspergillus oryzae

dc.creatorJusto, GZ
dc.creatorDuran, N
dc.creatorQueiroz, MLS
dc.date2000
dc.dateFEB 4
dc.date2014-12-02T16:28:13Z
dc.date2015-11-26T16:36:24Z
dc.date2014-12-02T16:28:13Z
dc.date2015-11-26T16:36:24Z
dc.date.accessioned2018-03-28T23:19:07Z
dc.date.available2018-03-28T23:19:07Z
dc.identifierEuropean Journal Of Pharmacology. Elsevier Science Bv, v. 388, n. 3, n. 219, n. 226, 2000.
dc.identifier0014-2999
dc.identifierWOS:000085352700003
dc.identifier10.1016/S0014-2999(99)00851-1
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/81934
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/81934
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/81934
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1271799
dc.descriptionThe effects of magnesium ammonium phospholinoleate-palmitoleate anhydride (MAPA), a proteic aggregated polymer isolated from Aspergillus oryzae, on the growth and differentiation of granulocyte-macrophage progenitor cells (colony-forming unit-granulocyte-macrophage [CFU-GM]) in normal and Ehrlich ascites tumour-bearing mice were studied. Myelosuppression concomitant with increased numbers of spleen CFU-GM was observed in tumour-bearing mice. Treatment of these animals with MAPA (0.5 - 10 mg/kg) stimulated marrow myelopoiesis in a dose-dependent manner and reduced spleen colony formation. No changes were observed in total and differential marrow cell counts. The dose of 5.0 mg/kg MAPA, given prior or after tumour inoculation, was the optimal biologically active dose in tumour-bearing mice and this dose schedule also stimulated myelopoiesis in normal mice. MAPA significantly enhanced survival and concurrently reduced tumour growth in the peritoneal cavity. We propose that the modulatory effect of MAPA on the myelopoietic response may be related to its antitumour activity as a possible mechanism for regulation of granulocyte-macrophage production and expression of functional activities. (C) 2000 Elsevier Science B.V. All rights reserved.
dc.description388
dc.description3
dc.description219
dc.description226
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationEuropean Journal Of Pharmacology
dc.relationEur. J. Pharmacol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectEhrlich ascites tumour
dc.subjectantitumour
dc.subjectmyelopoiesis
dc.subjectMAPA (magnesium ammonium phospholinoleate-palmitoleate anhydride)
dc.subjectCFU-GM (colony-forming unit-granulocyte-macrophage)
dc.subjectNecrosis-factor-alpha
dc.subjectColony-stimulating Factors
dc.subjectSuppressor Cells
dc.subjectEhrlich Tumor
dc.subjectIfn-gamma
dc.subjectGrowth
dc.subjectMacrophages
dc.subjectCancer
dc.subjectProstaglandin-e(2)
dc.subjectDifferentiation
dc.titleMyelopoietic response in tumour-bearing mice by an aggregated polymer isolated from Aspergillus oryzae
dc.typeArtículos de revistas


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