Artículos de revistas
Evidence of memory impairment in asymptomatic individuals with hippocampal atrophy
Registro en:
Epilepsy & Behavior. Academic Press Inc Elsevier Science, v. 5, n. 6, n. 981, n. 987, 2004.
1525-5050
WOS:000225874100026
10.1016/j.yebeh.2004.08.018
Autor
Alessio, A
Kobayashi, E
Damasceno, BP
Lopes-Cendes, I
Cendes, F
Institución
Resumen
Our objective was to investigate if MRI-determined hippocampal atrophy (HA) is associated with memory deficits independent of seizure frequency. We studied three groups of individuals: (1) 10 asymptomatic first-degree relatives of patients with familial mesial temporal lobe epilepsy (FMTLE), all of them with HA; (2) 14 patients with benign FMTLE, 9 with HA, and 5 with normal hippocampal volumes; and (3) 16 patients with refractory FMTLE, all but one with HA. HA was associated with lower scores on general memory (P = 0.015), verbal memory (P = 0.020), and delayed recall (P = 0.028), even in those with no or few seizures in life. General linear model analyses showed that the interaction between seizure outcome and HA was associated with worse verbal memory (P = 0.029), visual memory (P = 0.022), and delayed recall (P = 0.039) as compared with each of these factors independently. Our findings suggest that seizures and HA are independently associated with memory impairment. (C) 2004 Elsevier Inc. All rights reserved. 5 6 981 987