Artículos de revistas
Paucity of Plasmodium vivax Mature Schizonts in Peripheral Blood Is Associated With Their Increased Cytoadhesive Potential
Registro en:
Journal Of Infectious Diseases. Oxford Univ Press Inc, v. 209, n. 9, n. 1403, n. 1407, 2014.
0022-1899
1537-6613
WOS:000334689700012
10.1093/infdis/jiu018
Autor
Lopes, SCP
Albrecht, L
Carvalho, BO
Siqueira, AM
Thomson-Luque, R
Nogueira, PA
Fernandez-Becerra, C
del Portillo, HA
Russell, BM
Renia, L
Lacerda, MVG
Costa, FTM
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) There is now a growing body of evidence that challenges the current view that Plasmodium vivax-infected erythrocyte (Pv-iE) are unable to sequester. Here we used ex vivo adhesion assays with Pv-iE before and after maturation to demonstrate a higher binding potential of schizonts compared to other asexual stages. These experimental results are correlated with our observations in a panel of 50 vivax malaria patients where schizonts were completely absent in 27 isolates, and few schizonts were observed in the remaining patients. These observations prompt a paradigm shift in P. vivax biology and open avenues to investigate the role of Pv-iE sequestration. 209 9 1403 1407 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Universal [470688/2012-2, 471066/2012-5] Doencas Negligenciadas [404154/2012-3] Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) FAPESP [2012/16525-2] Universal [470688/2012-2, 471066/2012-5] Doencas Negligenciadas [404154/2012-3]