Artículos de revistas
5-HT induces temporomandibular joint nociception in rats through the local release of inflammatory mediators and activation of local beta adrenoceptors
Registro en:
Pharmacology Biochemistry And Behavior. Pergamon-elsevier Science Ltd, v. 102, n. 3, n. 458, n. 464, 2012.
0091-3057
WOS:000307434500009
10.1016/j.pbb.2012.06.005
Autor
Oliveira-Fusaro, MCG
Clemente-Napimoga, JT
Teixeira, JM
Torres-Chavez, KE
Parada, CA
Tambeli, CH
Institución
Resumen
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) The 5-hydroxytryptamine (serotonin, 5-HT) is an important inflammatory mediator found in high levels in the synovial fluid of the temporomandibular joint (TMJ) of patients with inflammatory pain. In this study, we used the nociceptive behavior responses, measured as flinching the head and rubbing the orofacial region, as a nociceptive assay. We demonstrated that the local blockade of the 5-HT3 receptor and beta(1) or beta(2)-adrenoceptors, the depletion of norepinephrine in the sympathetic terminals and the local inhibition of cyclooxygenase significantly reduced 5-HT-induced TMJ nociception. These results demonstrated that 5-HT induces nociception in the TMJ region by the activation of beta(1) and beta(2) adrenoceptors located in the TMJ region and local release of sympathetic amines and prostaglandins. Therefore, the high levels of 5-HT in the synovial fluid of patients with TMJ inflammatory pain may contribute to TMJ pain by similar mechanisms. (c) 2012 Elsevier Inc. All rights reserved. 102 3 458 464 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)