Metabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects

dc.creatorLeanca, CC
dc.creatorNunes, VS
dc.creatorPanzoldo, NB
dc.creatorZago, VS
dc.creatorParra, ES
dc.creatorCazita, PM
dc.creatorJauhiainen, M
dc.creatorPassarelli, M
dc.creatorNakandakare, ER
dc.creatorde Faria, EC
dc.creatorQuintao, ECR
dc.date2013
dc.date44866
dc.date2014-07-30T14:01:26Z
dc.date2015-11-26T16:33:56Z
dc.date2014-07-30T14:01:26Z
dc.date2015-11-26T16:33:56Z
dc.date.accessioned2018-03-28T23:16:00Z
dc.date.available2018-03-28T23:16:00Z
dc.identifierCardiovascular Diabetology. Biomed Central Ltd, v. 12, 2013.
dc.identifier1475-2840
dc.identifierWOS:000329804400001
dc.identifier10.1186/1475-2840-12-173
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/56561
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/56561
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1271033
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionBackground: We have searched if plasma high density lipoprotein-cholesterol (HDL-C) concentration interferes simultaneously with whole-body cholesterol metabolism and insulin sensitivity in normal weight healthy adult subjects. Methods: We have measured the activities of several plasma components that are critically influenced by insulin and that control lipoprotein metabolism in subjects with low and high HDL-C concentrations. These parameters included cholesteryl ester transfer protein (CETP), phospholipid transfer protein (PLTP), lecithin cholesterol acyl transferase (LCAT), post-heparin lipoprotein lipase (LPL), hepatic lipase (HL), pre-beta-1HDL, and plasma sterol markers of cholesterol synthesis and intestinal absorption. Results: In the high-HDL-C group, we found lower plasma concentrations of triglycerides, alanine aminotransferase, insulin, HOMA-IR index, activities of LCAT and HL compared with the low HDL-C group; additionally, we found higher activity of LPL and pre-beta-1HDL concentration in the high-HDL-C group. There were no differences in the plasma CETP and PLTP activities. Conclusions: These findings indicate that in healthy hyperalphalipoproteinemia subjects, several parameters that control the metabolism of plasma cholesterol and lipoproteins are related to a higher degree of insulin sensitivity.
dc.description12
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [06/60585-9, 08/50185-9]
dc.languageen
dc.publisherBiomed Central Ltd
dc.publisherLondon
dc.publisherInglaterra
dc.relationCardiovascular Diabetology
dc.relationCardiovasc. Diabetol.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectInsulin resistance
dc.subjectHDL-C concentration
dc.subjectLipoprotein lipases
dc.subjectLecithin cholesterol acyl transferase
dc.subjectPre-beta1 HDL
dc.subjectPlasma cholesterol metabolism markers
dc.subjectCholesteryl ester transfer protein
dc.subjectPhospholipid transfer protein
dc.subjectHigh-density-lipoprotein
dc.subjectTransfer Protein-activity
dc.subjectType-2 Diabetes-mellitus
dc.subjectHepatic Lipase Activity
dc.subjectIntima-media Thickness
dc.subjectNondiabetic Subjects
dc.subjectEster Transfer
dc.subjectResistance
dc.subjectObesity
dc.subjectAcyltransferase
dc.titleMetabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects
dc.typeArtículos de revistas


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