Artículos de revistas
Low-level laser therapy (LLLT) (660 nm) alters gene expression during muscle healing in rats
Registro en:
Journal Of Photochemistry And Photobiology B-biology. Elsevier Science Sa, v. 120, n. 29, n. 35, 2013.
1011-1344
WOS:000317882100004
10.1016/j.jphotobiol.2013.01.002
Autor
Rodrigues, NC
Brunelli, R
de Araujo, HS
Parizotto, NA
Renno, ACM
Institución
Resumen
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Introduction: The effects of LLLT were studied during muscle regeneration through gene expression. Methods: It was evaluated 10 and 50 J/cm(2) doses during 7, 14 and 21 days post cryoinjury, through histopathological analysis and mRNA MyoD, Myogenin, Vegf and Cox-2 expression. Results: Irradiated groups presented less inflammatory process than control group after 14 and 21 days. Cox-2 levels were downregulated in all irradiated groups after 7, 14 and 21 days. On day 7, both treated groups had a downregulation of Vegf levels, and an upregulation after 14 and 21 days, mainly with 50 J/cm(2). The MyoD levels were upregulated with high dose in all periods and with low dose after 21 days. Myogenin expression was downregulated in both treated groups after 7 days, and was upregulated with 10 J/cm(2) after 21 days. Conclusion: These responses suggest that LLLT can improve the skeletal muscle regeneration through the gene expression stimulation. (C) 2013 Elsevier B.V. All rights reserved. 120 29 35 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)