Artículos de revistas
Preparation of Polymeric Nanoparticles by Polymerization of Monomers - Part I
Registration in:
Polimeros-ciencia E Tecnologia. Assoc Brasil Polimeros, v. 22, n. 1, n. 96, n. 100, 2012.
0104-1428
WOS:000302850900016
10.1590/S0104-14282012005000006
Author
Souto, EB
Severino, P
Santana, MHA
Institutions
Abstract
Polymeric nanoparticles obtained from synthetic polymers such as copolymers of methacrylic acid, acrylic esters or metacrylics, have been widely used in pharmaceuticals for encapsulation of drugs. These nanoparticles have the advantages of drug protection, controlled release, improved bioavailability and lower toxicity, resulting in greater comfort to patients and compliance to the treatment. The production of nanoparticles (nanospheres and nanocapsules) by polymerization of monomers is reviewed and discussed in this article, highlighting the technological parameters that affect the physicochemical characteristics of nanoparticles, e.g. drug solubility, phase volume, pH of polymerization, molecular weight and monomer concentration, and the nature and concentration of the surfactant. 22 1 96 100