Artículos de revistas
Acute leukemias in Piaui: comparison with features observed in other regions of Brazil
Brazilian Journal Of Medical And Biological Research. Assoc Bras Divulg Cientifica, v. 36, n. 3, n. 331, n. 337, 2003.
Differences in age and sex distribution as well as FAB (French-American-British classification) types have been reported for acute leukemias in several countries. We studied the demographics and response to treatment of patients with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) between 1989 and 2000 in Teresina, Piaui, and compared these results with reports from Brazil and other countries. Complete data concerning 345 patients (230 ALL, 115 AML) were reviewed. AML occurred predominantly in adults (77%), with a median age of 34 years, similar to that found in the southeast of Brazil but lower than the median age in the United States and Europe (52 years). FAB distribution was similar in children and adults and FAB-M2 was the most common type, as also found in Japan. The high frequency of FAB-M3 described in most Brazilian studies and for Hispanics in the United States was not observed. Overall survival for adults was 40%, similar to other studies in Brazil. A high mortality rate was observed during induction. No clinical or hematological parameter influenced survival in the Cox model. ALL presented the characteristic peak of incidence between 2-8 years. Most of the cases were CD10+pre-B ALL. In 25%, abnormal expression of myeloid antigens was observed. Only 10% of the patients were older than 30 years. Overall survival was better for children. Age and leukocyte count were independent prognostic factors. These data demonstrate that, although there are regional peculiarities, the application of standardized treatments and good supportive care make it possible to achieve results observed in other countries for the same chemotherapy protocols.363331337
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Cytotoxic effect of Spirulina platensis extracts on human acute leukemia Kasumi-1 and chronic myelogenous leukemia K-562 cell lines. Sanghamitra Khandual; FLOR YOHANA FLORES HERNANDEZ; INOCENCIA GUADALUPE RAMIREZ LOPEZ
A rare case of Acute Lymphocytic Leukemia (ALL) presenting with double Philadelphia chromosome: relapse or secondary leukemia? Campos, Mireille Guimarães Vaz de; Chauffaille, Maria de Lourdes Lopes Ferrari; Rodrigues, Celso Arrais; Krum, Everson A.; Yamamoto, Mihoko (Sociedade Brasileira de Genética, 2003-01-01)The Philadelphia chromosome is observed in 5% of pediatric acute lymphocytic leukemia (ALL) and in 25% to 50% of adult ALL cases, and is associated with poor prognosis. Double Ph in a hyperdiploid karyotype is common in ...
Current Patient Management of Chronic Myeloid Leukemia in Latin America A Study by the Latin American Leukemia Net (LALNET) CORTES, Jorge; SOUZA, Carmino De; AYALA-SANCHEZ, Manuel; BENDIT, Israel; BEST-AGUILERA, Carlos; ENRICO, Alicia; HAMERSCHLAK, Nelson; PAGNANO, Katia; PASQUINI, Ricardo; MEILLON, Luis (JOHN WILEY & SONS INC, 2010)BACKGROUND: Treatment recommendations have been developed for management of patients with chronic myeloid leukemia (CML). METHODS: A 30-item multiple-choice questionnaire was administered to 435 hematologists and ...