Artículos de revistas
Prophylactic administration of Withania somnifera extract increases host resistance in Listeria monocytogenes infected mice
Registro en:
International Immunopharmacology. Elsevier Science Bv, v. 6, n. 10, n. 1535, n. 1542, 2006.
1567-5769
WOS:000240374300002
10.1016/j.intimp.2006.03.016
Autor
Teixeira, ST
Valadares, MC
Goncalves, SA
de Melo, A
Queiroz, MLS
Institución
Resumen
In this study, we demonstrated that Withania somnifera L. extract (WSE) protects mice from a lethal dose of Listeria monocytogenes when administered prophylactically at 100, 250 and 500 mg/kg for 10 days, with survival rates up to 30%. These doses also prevented the myelosuppression and the splenomegaly caused by a sublethal infection with L. monocytogenes, due to increased numbers of granulocyte-macrophage progenitors (CFU-GM) in the bone marrow. Investigation of the production of colony-stimulating factors (CSFs) revealed increased colony-stimulating activity (CSA) in the serum of normal and infected mice pre-treated with WSE. Further studies to investigate the levels of interferon-gamma (INF-gamma) and lymphocyte cell proliferation were undertaken. We observed dose-dependent increases in cell proliferation and in the levels of INF-gamma in mice infected with L. monocytogenes and treated with WSE. All together, our results suggest that WSE indirectly modulates immune activity and probably disengages Listeria-induced suppression of these responses by inducing a higher reserve of myeloid progenitors in the bone marrow, proliferation of lymphocytes and increased INF-gamma levels. (c) 2006 Elsevier B.V. All rights reserved. 6 10 1535 1542