Artículos de revistas
THE SCN2A gene is not a likely candidate for familial mesial temporal lobe epilepsy
Registro en:
Epilepsy Research. Elsevier Science Bv, v. 71, n. 41700, n. 233, n. 236, 2006.
0920-1211
WOS:000241310300017
10.1016/j.eplepsyres.2006.06.016
Autor
Maurer-Morelli, CV
Secolin, R
Marchesini, RB
Santos, NF
Kobayashi, E
Cendes, F
Lopes-Cendes, I
Institución
Resumen
A transgenic mouse model carrying a mutation in the Scn2a gene showed chronic focal seizures associated with extensive cell loss and gliosis in the hippocampus, a similar phenotype found in familial mesial temporal lobe epilepsy (FMTLE). Our objective was to test whether the human homolog of the Scn2a gene is responsible for hippocampal abnormalities in FMTLE by linkage analysis. We conclusively ruled out the SCN2A gene as candidate in FMTLE. (c) 2006 Elsevier B.V. All rights reserved. 71 41700 233 236