Landau-Kleffner syndrome: Long-term follow-up

dc.creatorDuran, MHC
dc.creatorGuimaraes, CA
dc.creatorMedeiros, LL
dc.creatorGuerreiro, MM
dc.date2009
dc.dateJAN
dc.date2014-11-16T02:08:06Z
dc.date2015-11-26T16:18:29Z
dc.date2014-11-16T02:08:06Z
dc.date2015-11-26T16:18:29Z
dc.date.accessioned2018-03-28T23:01:59Z
dc.date.available2018-03-28T23:01:59Z
dc.identifierBrain & Development. Elsevier Science Bv, v. 31, n. 1, n. 58, n. 63, 2009.
dc.identifier0387-7604
dc.identifierWOS:000262539500010
dc.identifier10.1016/j.braindev.2008.09.007
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/61097
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/61097
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/61097
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1267590
dc.descriptionPurpose: Landau-Kleffner syndrome (LKS) is a rare entity characterized by epilepsy and aphasia. It occurs in previously normal children, usually between three and seven years of age. The long-term outcome of LKS is not completely clear. The aim of this study is to verify the long-term follow-up of a group of patients with LKS, focusing on clinical and electroencephalographic (EEG) aspects, and quality of life. Methods: This was a transversal study. Between November 2006 and April 2007 seven patients with previous diagnosis of LKS were interviewed. They had had a follow-Lip of three to 16 years after their disease onset. They were all males between the ages of eight and 27 years old. All patients had normal MRI. Parents and/or patients were interviewed by one of the authors using a structured questionnaire. The Vineland Adaptive Behavior Scales, the Conner's Rating Scales - Revised, and Short-Form Health Survey (SF 36) were used. Each patient had a prolonged interictal EEG recording. All patients had normal MRI. Results: The present investigation revealed that two patients still have seizures several years after epilepsy onset. One patient had total and three others had partial remission of language disturbance, while three patients still have aphasia and verbal auditory agnosia. With respect to quality of life, only one of our patients has a normal life at present. The remaining six patients with some sort of limitation consider the aphasia/agnosia to be the main difficulty in their lives. Five patients have normal EEGs. Conclusions: The long-term follow-up of patients with LKS shows that epilepsy and EEG abnormalities do not always disappear. Language disturbances tend to persist in most patients. The age of onset of language dysfunction does not seem to correlate with the prognosis for recovery of language function. Patients with LKS have an overall poor quality of life, mostly due to language difficulties. (C) 2008 Elsevier B.V. All rights reserved.
dc.description31
dc.description1
dc.description58
dc.description63
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationBrain & Development
dc.relationBrain Dev.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectLandau-Kleffner Syndrome
dc.subjectEpilepsy
dc.subjectChildhood
dc.subjectAphasia
dc.subjectAgnosia
dc.subjectFollow-up
dc.subjectElectrical Status Epilepticus
dc.subjectAcquired Aphasia
dc.subjectConvulsive Disorder
dc.subjectLanguage Regression
dc.subjectChildhood
dc.subjectSleep
dc.subjectEpilepsy
dc.subjectChildren
dc.titleLandau-Kleffner syndrome: Long-term follow-up
dc.typeArtículos de revistas


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