Investigation of the haemodynamic effects of Phoneutria nigriventer venom in anaesthetised rabbits

dc.creatorEstato, V
dc.creatorAntunes, E
dc.creatorMachado, B
dc.creatorDe Nucci, G
dc.creatorTibirica, E
dc.date2000
dc.dateJUN
dc.date2014-12-02T16:25:18Z
dc.date2015-11-26T16:13:51Z
dc.date2014-12-02T16:25:18Z
dc.date2015-11-26T16:13:51Z
dc.date.accessioned2018-03-28T23:01:18Z
dc.date.available2018-03-28T23:01:18Z
dc.identifierToxicon. Pergamon-elsevier Science Ltd, v. 38, n. 6, n. 841, n. 853, 2000.
dc.identifier0041-0101
dc.identifierWOS:000085026100008
dc.identifier10.1016/S0041-0101(99)00198-1
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/60638
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/60638
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/60638
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1267423
dc.descriptionThe haemodynamic alterations induced by the central and peripheral administration of the armed spider (Phoneutria nigriventer) venom (PNV) were investigated in anaesthetised rabbits. The intracerebroventricular injection of increasing doses of PNV (30 and 100 mu g/ kg) elicited a biphasic cardiovascular response characterised by a brief hypotension (1-3 min) followed by a marked and sustained (more than 30 min) increase in mean arterial pressure (61 +/- 5 and 61 +/- 10%, respectively) and in systemic vascular resistance (135 +/- 21 and 161 + 37%) accompanied by mild increases in cardiac contractility. Systemic alterations such as salivation and muscular fasciculation were also observed. At the opposite, the dose of 100 mu g/kg of PNV injected intravenously produced only a hypotensive effect (29 +/- 4% decrease in mean arterial pressure) and a decrease in vascular resistance (38 +/- 5%). Nevertheless, a much higher dose of PNV (1 mg/kg) injected intravenously produced a hypertensive response analogous to the one observed upon central administration. The central hypertensive response induced by PNV was not affected by pretreating the animals with selective antagonists of receptors of different neurotransmitters or endogenous mediators such as: acethylcoline muscarinic, bradykinin B-2, angiotensin II AT(1) receptors and also antagonists of the excitatory aminoacid receptors of the central nervous system. Nevertheless, the intravenous pretreatment with the selective al-adrenergic receptor antagonist prazosin significantly blunted the excitatory cardiovascular response evoked by the central injection of PNV. It is concluded that PNV call induce central as well as peripheral haemodynamic effects. The central component seems to be mediated by the activation of cardiovascular centres which in turn lead to an increase in the sympathetic outflow to the periphery, whereas the peripheral component can be accounted for either by direct activation of the vascular;alpha(1)-adrenergic receptors or by catecholamine release from the sympathetic nerve endings. (C) 2000 Elsevier Science Ltd. All rights reserved.
dc.description38
dc.description6
dc.description841
dc.description853
dc.languageen
dc.publisherPergamon-elsevier Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationToxicon
dc.relationToxicon
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectPhoneutria nigriventer
dc.subjectspider venom
dc.subjectarterial pressure
dc.subjectvasoconstriction
dc.subjectcentral nervous system
dc.subjectArmed Spider Venom
dc.subjectKininogen-kinin System
dc.subjectSubfornical Organ
dc.subjectAngiotensin-ii
dc.subjectSkin Invivo
dc.subjectRat
dc.subjectActivation
dc.subjectPressor
dc.titleInvestigation of the haemodynamic effects of Phoneutria nigriventer venom in anaesthetised rabbits
dc.typeArtículos de revistas


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