The total synthesis of (+/-)-homopumiliotoxin 223G was achieved in six steps and 14% yield through the addition of 5-methyl-2-triisopropylsilyoxyfuran (3) to the N-acyliminium ion derived from N-Cbz 2-methoxypiperidine featurign bicyclic lactam 9b as th ekey intermediate. (C) 2001 Elsevier Science Ltd. All rights reserved.424069997001