The total synthesis of the polyketide antibiotic (-)-basiliskamide B is described. The convergent asymmetric synthesis relies on the use of a diastereoselective ethyl ketone aldol reaction followed by a syn selective reduction of a beta-hydroxy ketone and a Stille cross-coupling between a Z-vinylstannane and an E-vinyl iodide to establish the (Z,E)dienamide moiety.3504185810171021