Circulating ghrelin concentrations are lowered by intracerebroventricular insulin

dc.creatorUeno, M
dc.creatorCarvalheira, JBC
dc.creatorOliveira, RLGS
dc.creatorVelloso, LA
dc.creatorSaad, MJA
dc.date2006
dc.dateOCT
dc.date2014-11-15T16:41:03Z
dc.date2015-11-26T16:12:19Z
dc.date2014-11-15T16:41:03Z
dc.date2015-11-26T16:12:19Z
dc.date.accessioned2018-03-28T23:00:34Z
dc.date.available2018-03-28T23:00:34Z
dc.identifierDiabetologia. Springer, v. 49, n. 10, n. 2449, n. 2452, 2006.
dc.identifier0012-186X
dc.identifierWOS:000240362000026
dc.identifier10.1007/s00125-006-0371-8
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/55937
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/55937
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/55937
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1267245
dc.descriptionAims/hypothesis: Ghrelin is a peptide that is mainly produced by the stomach and stimulates food intake, adiposity and weight gain. Previous studies have documented that plasma levels of ghrelin are reduced by insulin, but the mechanisms that mediate this effect are unclear. Methods: To determine whether phosphatidylinositol 3-kinase (PI(3)K) and/or mitogen-activated protein kinase (MAPK) are involved in this insulin action, we tested the intracerebroventricular (i.c.v.) effect of specific inhibitors of PI(3)K (LY294002 and wortmannin) and MAPK (PD98059 and UO126) on the insulin-mediated reduction of ghrelin levels in rats. Results: Intracerebroventricular treatment with insulin reduced ghrelin levels. Inhibition of PI(3)K specifically blocked the insulin-induced reduction in ghrelin concentration, whereas inhibition of MAPK had no effect on insulin-mediated actions. Moreover, pretreatment with i.c.v. PI(3)K inhibitors blocked the reduction of ghrelin levels after OGTT-induced hyperglycaemia and hyperinsulinaemia. Conclusions/interpretation: These data demonstrate that changes in insulin action in the central nervous system regulate circulating ghrelin levels and that PI(3)K is a specific mediator of this action.
dc.description49
dc.description10
dc.description2449
dc.description2452
dc.languageen
dc.publisherSpringer
dc.publisherNew York
dc.publisherEUA
dc.relationDiabetologia
dc.relationDiabetologia
dc.rightsfechado
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.sourceWeb of Science
dc.subjectCNS
dc.subjectghrelin
dc.subjectinsulin
dc.subjectAcylated Peptide
dc.subjectFood-intake
dc.subjectGlucose
dc.subjectObesity
dc.subjectHumans
dc.subjectRats
dc.titleCirculating ghrelin concentrations are lowered by intracerebroventricular insulin
dc.typeArtículos de revistas


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