Artículos de revistas
Short synthesis of the 6,6-spiroketal cores of spirofungins A and B
Registro en:
Organic Letters. Amer Chemical Soc, v. 6, n. 15, n. 2587, n. 2590, 2004.
1523-7060
WOS:000222706600025
10.1021/ol0491078
Autor
Dias, LC
de Oliveira, LG
Institución
Resumen
Initial efforts toward the total synthesis of the antifungal antibiotics spirofungins A and B are reported. A short and efficient synthesis of the C9-C20 6,6-spiroketal fragments of both compounds is described. This asymmetric approach uses a very efficient alkylation of a lithiated N,N-dimethylhydrazone followed by spiroketal formation under acidic conditions. 6 15 2587 2590