Colchicine attenuates left ventricular hypertrophy but preserves cardiac function of aortic-constricted rats

dc.creatorScopacasa, BS
dc.creatorTeixeira, VPA
dc.creatorFranchini, KG
dc.date2003
dc.dateAPR
dc.date2014-11-15T12:21:23Z
dc.date2015-11-26T16:11:00Z
dc.date2014-11-15T12:21:23Z
dc.date2015-11-26T16:11:00Z
dc.date.accessioned2018-03-28T22:59:37Z
dc.date.available2018-03-28T22:59:37Z
dc.identifierJournal Of Applied Physiology. Amer Physiological Soc, v. 94, n. 4, n. 1627, n. 1633, 2003.
dc.identifier8750-7587
dc.identifierWOS:000181426300041
dc.identifier10.1152/japplphysiol.00744.2002
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/78920
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/78920
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/78920
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1267014
dc.descriptionTo investigate the effects of colchicine on left ventricular (LV) function and hypertrophy (LVH) of rats subjected to constriction of transverse aorta (TAoC), we evaluated SO (sham operated, vehicle; n = 25), SO-T (sham operated, colchicine 0.4 mg/kg body wt ip daily; n = 38), TAoC (vehicle; n = 37), and TAoC-T (TAX, colchicine; n = 34) on the 2nd, 6th, and 15th day after surgery. Colchicine attenuated LVH of TAoC-T compared with TAoC rats, as evaluated by ratio between LV mass (LVM) and right ventricular mass, LV wall thickness, and average diameter of cardiac myocytes. Systolic gradient across TAoC (similar to45 mmHg), LV systolic pressure, LV end-diastolic pressure, and rate of LV pressure increase (+dP/dt) were comparable in TAoC-T and TAoC rats. However, the baseline and increases of LV systolic pressure-to-LVM and +dP/dt-to-LVM ratios induced by phenylephrine infusion were greater in TAoC-T and SO-T compared with SO rats. Baseline and increases of +dP/dt-to-LVM ratio were reduced in TAoC compared with SO rats. TAoC rats increased polymerized fraction of tubulin compared with SO, SO-T, and TAoC-T rats. Our results indicate that colchicine treatment reduced LVH to pressure overload but preserved LV function.
dc.description94
dc.description4
dc.description1627
dc.description1633
dc.languageen
dc.publisherAmer Physiological Soc
dc.publisherBethesda
dc.publisherEUA
dc.relationJournal Of Applied Physiology
dc.relationJ. Appl. Physiol.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectmyocardium
dc.subjectmicrotubules
dc.subjectcytoskeleton
dc.subjectDilated Cardiomyopathy
dc.subjectContractile Dysfunction
dc.subjectCytoskeletal Role
dc.subjectMicrotubules
dc.subjectMutations
dc.subjectMetavinculin
dc.subjectCardiocytes
dc.subjectDeficiency
dc.subjectMyocardium
dc.subjectMyocytes
dc.titleColchicine attenuates left ventricular hypertrophy but preserves cardiac function of aortic-constricted rats
dc.typeArtículos de revistas


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