Artículos de revistas
Synthesis, anti-inflammatory and antimicrobial activities of new 1,2,4-oxadiazoles peptidomimetics
Registro en:
Farmaco. Elsevier Science Sa, v. 55, n. 41984, n. 719, n. 724, 2000.
0014-827X
WOS:000166208000010
10.1016/S0014-827X(00)00099-9
Autor
Leite, ACL
Vieira, RF
de Faria, AR
Wanderley, AG
Afiatpour, P
Ximenes, ECPA
Srivastava, RM
de Oliveira, CF
Medeiros, MV
Antunes, E
Brondani, DJ
Institución
Resumen
A new series of 1,2,4-oxadizoles 6a-g have been synthesised in good yields using the peptide synthesis strategy. The prepared compounds were tested for anti-inflammatory and antimicrobial activities. The anti-inflammatory activities were determined in the rat paw oedema induced by carrageenin. Compounds 6a, c, f and g (i.v.) significantly inhibited the rat paw oedema induced by carrageenin depending upon the dose employed. The compounds were also evaluated for their in vitro antimicrobial activity. Some compounds were found to have significant activity against Gram positive and Gram negative microorganisms. (C) 2000 Elsevier Science S.A. All rights reserved. 55 41984 719 724