Boron-Doped Diamond Electrode Coupled to Liquid Chromatography: Application to Simultaneous Determination of Benzodiazepines

dc.creatorMartins, I
dc.creatorCanaes, LD
dc.creatorDoretto, KM
dc.creatorRath, S
dc.date2010
dc.dateFEB
dc.date2014-11-15T02:42:28Z
dc.date2015-11-26T16:09:24Z
dc.date2014-11-15T02:42:28Z
dc.date2015-11-26T16:09:24Z
dc.date.accessioned2018-03-28T22:58:00Z
dc.date.available2018-03-28T22:58:00Z
dc.identifierElectroanalysis. Wiley-v C H Verlag Gmbh, v. 22, n. 4, n. 455, n. 462, 2010.
dc.identifier1040-0397
dc.identifierWOS:000275039600014
dc.identifier10.1002/elan.200900346
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/78208
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/78208
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/78208
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1266610
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionThe applicability of boron-doped diamond (BDD) as a working electrode in an amperometric cell, coupled to HPLC, was demonstrated, for determining benzodiazepines in pharmaceutical preparations. The separation of the benzodiazepines was achieved using a Waters XTerra RP 18 column (250 x 4.6 mm, 5 mu m) with a mobile phase sodium phosphate (pH 3.5; 0.10 mol L(-1))-acetonitrile (65:35, v/v) at flow of 1.2 mL min(-1). The measurements were performed in a system 871 Advanced Bioscan (Metrohm) with a BDD (8000 ppm) adapted to the thin layer mode cell. Stainless steel and platinum wire were used as reference and auxiliary electrodes, respectively. The cell was operated in pulse mode, using -1.9 V as initial potential. The method presented linearity, repeatability and ruggedness and it represents a novel, alternative electroanalytical method for benzodiazepines determination.
dc.description22
dc.description4
dc.description455
dc.description462
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherWiley-v C H Verlag Gmbh
dc.publisherWeinheim
dc.publisherAlemanha
dc.relationElectroanalysis
dc.relationElectroanalysis
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectBoron-doped diamond (BDD)
dc.subjectAmperometric detection
dc.subjectHigh-performance liquid chromatography with electrochemical detection (HPLC-ED)
dc.subjectBenzodiazepines
dc.subjectPharmaceutical formulations
dc.subjectElectrochemical Detection
dc.subjectElectroanalytical Determination
dc.subjectPotentiometric Determination
dc.subjectPharmaceutical-preparations
dc.subjectVoltammetric Determination
dc.subjectDiazepam
dc.subject1,4-benzodiazepines
dc.subjectOxazepam
dc.subjectSamples
dc.subjectHplc
dc.titleBoron-Doped Diamond Electrode Coupled to Liquid Chromatography: Application to Simultaneous Determination of Benzodiazepines
dc.typeArtículos de revistas


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