The association of cytokine gene polymorphisms with febrile non-hemolytic transfusion reaction in multitransfused patients

dc.creatorAddas-Carvalho, M
dc.creatorSalles, TSI
dc.creatorSaad, STO
dc.date2006
dc.dateJUN
dc.date2014-11-14T20:21:58Z
dc.date2015-11-26T16:08:18Z
dc.date2014-11-14T20:21:58Z
dc.date2015-11-26T16:08:18Z
dc.date.accessioned2018-03-28T22:56:51Z
dc.date.available2018-03-28T22:56:51Z
dc.identifierTransfusion Medicine. Blackwell Publishing, v. 16, n. 3, n. 184, n. 191, 2006.
dc.identifier0958-7578
dc.identifierWOS:000237999100005
dc.identifier10.1111/j.1365-3148.2006.00665.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/78359
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/78359
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/78359
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1266325
dc.descriptionCytokines are associated with inflammatory responses including febrile non-hemolytic transfusion reactions (FNHTR). Moreover, there are some polymorphisms of these cytokine genes associated with different levels of gene expression. The aim of the present study was to investigate the association of inflammatory cytokine gene polymorphisms with the occurrence of FNHTR in multitransfused patients. We studied two groups of transfused patients: one presenting FNHTR before 20 transfusions of red blood cells concentrates and the other which never presented FNHTR even after 20 transfusions. The gene polymorphisms studied were IL1B - 511C/T and +3953C/T, IL1RN ( intron 2, variable number tandem repeat), IL6-174G/C, IL10 - 1082G/A and - 819C/T, TNF-308G/A and LTA+253G/A using polymerase chain reaction and restriction digestion or sequencing methods. An association of IL1RN*2.2 genotype with the occurrence of precocious FNHTR ( P < 0.025) was detected. This allele and this genotype have been related with higher serum levels of interleukin (IL)-1 beta in vivo and higher promoter activity. No other association was demonstrated. The association of gene polymorphisms related with the increase of inflammatory cytokine gene expression may be a relevant factor in FNHTR and requires confirmation.
dc.description16
dc.description3
dc.description184
dc.description191
dc.languageen
dc.publisherBlackwell Publishing
dc.publisherOxford
dc.publisherInglaterra
dc.relationTransfusion Medicine
dc.relationTransfus. Med.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectblood transfusion
dc.subjectcytokine
dc.subjectgene polymorphism
dc.subjecttransfusion reaction
dc.subjectReceptor Antagonist Gene
dc.subjectInterleukin-6 Il-6 Gene
dc.subjectRed-cell Transfusions
dc.subjectTandem Repeat
dc.subjectTnf-alpha
dc.subjectPlatelet
dc.subjectPlasma
dc.subjectIl-1ra
dc.subjectPromoter
dc.subjectIntron-2
dc.titleThe association of cytokine gene polymorphisms with febrile non-hemolytic transfusion reaction in multitransfused patients
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución