HPV-DNA Hybrid Capture Test Influence of Cellularity in Penile Samples

dc.creatorEleuterio, J
dc.creatorBarros, IC
dc.creatorCavalcante, DIM
dc.creatorEleuterio, RMN
dc.creatorGiraldo, PC
dc.date2010
dc.dateJUL-AUG
dc.date2014-11-14T14:44:09Z
dc.date2015-11-26T16:07:07Z
dc.date2014-11-14T14:44:09Z
dc.date2015-11-26T16:07:07Z
dc.date.accessioned2018-03-28T22:55:50Z
dc.date.available2018-03-28T22:55:50Z
dc.identifierActa Cytologica. Sci Printers & Publ Inc, v. 54, n. 4, n. 546, n. 550, 2010.
dc.identifier0001-5547
dc.identifierWOS:000280081100002
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/68885
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/68885
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/68885
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1266059
dc.descriptionObjective To evaluate if the cellularity of Hybrid Capture samples (Digene, Sao Paulo, Brazil) influences the results of HPV-DNA Hybrid Capture tests in men. Study Design We harvested material from penile scrapings for the Hybrid Capture HPV test. This material was then used to make cytologic smears, which we used to evaluate for the presence of nonnucleated squamous cells, nucleated squamous cells and glandular cells. The cellularity of nucleated squamous cells was classified as absent, low, moderate or high. Subsequently, we performed the Hybrid Capture test to identify the low and high risk of HPV and compared these results with the cytologic findings. We used the Fisher and odds ratio tests at CI of 95% to determine statistical significance. Results Of the 88 tests performed, 65 (74.0%) were negative for HPV-DNA and 23 (26.0%) were positive. Nucleated and nonnucleated squamous cells were absent on nine slides, all of which tested negative for HPV. When only nonnucleated squamous cells were found, 20% of the cases were positive for HPV-DNA (p<0.0001, OR = 26.185). The presence of nucleated squamous cells correlated with 33% HPV-DNA positivity (p <0.0001, OR = 49.05). Conclusion Assessing the presence of non-nucleated and nucleated squamous cells on cytologic smears prior to performing an HPV-DNA test is a useful tool for quality control in penile samples. (Acta Cytol 2010;54:546-550)
dc.description54
dc.description4
dc.description546
dc.description550
dc.languageen
dc.publisherSci Printers & Publ Inc
dc.publisherSt Louis
dc.publisherEUA
dc.relationActa Cytologica
dc.relationActa Cytol.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectHybrid Capture
dc.subjectpapillomavirus infections
dc.subjectpenile diseases
dc.subjectHuman-papillomavirus Infection
dc.subjectMale Sexual Partners
dc.subjectCervical Intraepithelial Neoplasia
dc.subjectWomen
dc.subjectMen
dc.subjectLesions
dc.subjectDiagnosis
dc.subjectSites
dc.titleHPV-DNA Hybrid Capture Test Influence of Cellularity in Penile Samples
dc.typeArtículos de revistas


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