SARCOPLASMIC-ENDOPLASMIC-RETICULUM CA(2+)-ATPASE AND CALSEQUESTRIN ARE OVEREXPRESSED IN SPARED INTRINSIC LARYNGEAL MUSCLES OF DYSTROPHIN-DEFICIENT MDX MICE

dc.creatorFerretti, R
dc.creatorMarques, MJ
dc.creatorPertille, A
dc.creatorNeto, HS
dc.date2009
dc.dateMAY
dc.date2014-11-20T05:35:06Z
dc.date2015-11-26T16:07:00Z
dc.date2014-11-20T05:35:06Z
dc.date2015-11-26T16:07:00Z
dc.date.accessioned2018-03-28T22:55:47Z
dc.date.available2018-03-28T22:55:47Z
dc.identifierMuscle & Nerve. John Wiley & Sons Inc, v. 39, n. 5, n. 609, n. 615, 2009.
dc.identifier0148-639X
dc.identifierWOS:000265450000007
dc.identifier10.1002/mus.21154
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/71654
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/71654
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/71654
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1266051
dc.descriptionIn the mdx mouse model of Duchenne muscular dystrophy, the lack of dystrophin is associated with increased calcium levels and skeletal muscle myonecrosis. The intrinsic laryngeal muscles (ILM) are protected and do not undergo myonecrosis. We investigated whether this protection is related to an increased expression of calcium-binding proteins, which may protect against the elevated calcium levels seen in dystrophic fibers. The expression of sarcoplasmic-endoplasmic-reticulum Ca(2+)-ATPase and calsequestrin was examined in ILM and in nonspared limb muscles of control and mdx mice using immunofluorescence and immunoblotting. Dystrophic ILM presented a significant increase in the proteins studied when compared to controls. The increase of Ca(2+)-handling proteins in dystrophic ILM may permit better maintenance of calcium homeostasis, with the consequent absence of myonecrosis. The results further support the concept that abnormal Ca(2+)-handling is involved in dystrophinopathies.
dc.description39
dc.description5
dc.description609
dc.description615
dc.languageen
dc.publisherJohn Wiley & Sons Inc
dc.publisherHoboken
dc.publisherEUA
dc.relationMuscle & Nerve
dc.relationMuscle Nerve
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectcalsequestrin
dc.subjectDuchenne Muscular dystrophy
dc.subjectintrinsic laryngeal muscles
dc.subjectmdx mice
dc.subjectSERCA1
dc.subjectDuchenne Muscular-dystrophy
dc.subjectSkeletal-muscle
dc.subjectExtraocular-muscle
dc.subjectNeuromuscular-junction
dc.subjectCalcium Homeostasis
dc.subjectDrastic Reduction
dc.subjectCardiac-muscle
dc.subjectExpression
dc.subjectMouse
dc.subjectFibers
dc.titleSARCOPLASMIC-ENDOPLASMIC-RETICULUM CA(2+)-ATPASE AND CALSEQUESTRIN ARE OVEREXPRESSED IN SPARED INTRINSIC LARYNGEAL MUSCLES OF DYSTROPHIN-DEFICIENT MDX MICE
dc.typeArtículos de revistas


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