The insulin tolerance test in morbidly obese patients undergoing bariatric surgery

dc.creatorGeloneze, B
dc.creatorTambascia, MA
dc.creatorPareja, JC
dc.creatorRepetto, EM
dc.creatorMagna, LA
dc.date2001
dc.dateDEC
dc.date2014-11-14T13:21:13Z
dc.date2015-11-26T16:06:42Z
dc.date2014-11-14T13:21:13Z
dc.date2015-11-26T16:06:42Z
dc.date.accessioned2018-03-28T22:55:31Z
dc.date.available2018-03-28T22:55:31Z
dc.identifierObesity Research. North Amer Assoc Study Obesity, v. 9, n. 12, n. 763, n. 769, 2001.
dc.identifier1071-7323
dc.identifierWOS:000172892000005
dc.identifier10.1038/oby.2001.105
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/73544
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/73544
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/73544
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1265979
dc.descriptionObjective: To assess the effect of massive weight loss in relation to insulin resistance and its correlation to changes in glycemic homeostasis and lipid profile in severely obese patients, Research Methods and Procedures: A prospective clinical intervention study was carried out with 31 morbidly obese women (body mass index: 54.2 +/- 8.8 kg/m(2)) divided into three groups according to their glucose tolerance test: 14 normal, 8 impaired glucose tolerance, and 9 type 2 diabetes. All subjects underwent an insulin tolerance test with intravenous bolus of 0.1 U insulin/kg body weight before silastic ring vertical gastroplasty Roux-en-Y gastric bypass surgery, and again at 2, 4, 6, and 12 months postoperatively. Fasting plasma glucose., hemoglobin Alc, and lipid profile were also evaluated. Results: A reduction of 68 +/- 15% in initial excess body weight was evident within 1 year. Along with weight loss, the following statistically significant changes were found: an increase in the insulin-sensitivity index (Kitt) and a decrease in fasting plasma glucose and hemoglobin Atc, most notably in the type 2 diabetes group. An overall improvement in lipid profile was observed in all three groups. Discussion: Bariatric surgery was an effective therapeutic approach for these obese patients because it reduced both weight and insulin resistance, alone, with improving metabolic parameters. Significant correlations were found between insulin resistance and metabolic improvements. Weight loss after bariatric surgery induced an improvement in metabolic fitness, related to the reduction in insulin resistance over a range of glucose tolerance statuses from normal to diabetic.
dc.description9
dc.description12
dc.description763
dc.description769
dc.languageen
dc.publisherNorth Amer Assoc Study Obesity
dc.publisherSilver Spring
dc.publisherEUA
dc.relationObesity Research
dc.relationObes. Res.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectbariatric surgery
dc.subjectweight loss
dc.subjectdiabetes
dc.subjectinsulin resistance
dc.subjectinsulin-sensitivity index (Kitt)
dc.subjectGastric Bypass-surgery
dc.subjectWeight-loss
dc.subjectBody-composition
dc.subjectSeverely Obese
dc.subjectGlucose-tolerance
dc.subjectDiabetes-mellitus
dc.subjectSurgical-treatment
dc.subjectLong-term
dc.subjectResistance
dc.subjectSensitivity
dc.titleThe insulin tolerance test in morbidly obese patients undergoing bariatric surgery
dc.typeArtículos de revistas


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