Morphometric evaluation of gingival overgrowth and regression caused by cyclosporin in rats

dc.creatorSpolidorio, LC
dc.creatorMerzel, J
dc.creatorVillalba, H
dc.creatorVargas, PA
dc.creatorColetta, RD
dc.creatorAlmeida, OP
dc.date2001
dc.dateDEC
dc.date2014-11-14T11:21:12Z
dc.date2015-11-26T16:06:08Z
dc.date2014-11-14T11:21:12Z
dc.date2015-11-26T16:06:08Z
dc.date.accessioned2018-03-28T22:55:03Z
dc.date.available2018-03-28T22:55:03Z
dc.identifierJournal Of Periodontal Research. Munksgaard Int Publ Ltd, v. 36, n. 6, n. 384, n. 389, 2001.
dc.identifier0022-3484
dc.identifierWOS:000172459300006
dc.identifier10.1034/j.1600-0765.2001.360606.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/82254
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/82254
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/82254
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1265862
dc.descriptionCyclosporin A is a selective immunosuppressant, used in organ transplants to prevent graft rejection. Cyclosporin A can cause various side effects including gingival overgrowth. The aim of this work was to evaluate gingival overgrowth of rats treated daily with 10 mg/kg body weight of cyclosporin A for 60 days, as well as the regression after the interruption of treatment. All rats treated with cyclosporin A developed gingival overgrowth, with increased thickness of the epithelium, height and width of the connective tissue. The density of fibroblasts and collagen fibers also increased. Five to 90 days after the interruption of treatment with cyclosporin A, there was a progressive reduction of the gingival volume and of collagen fibers and fibroblast densities. The reduction was more pronounced in the initial periods and after 90 days did not return to the normal values.
dc.description36
dc.description6
dc.description384
dc.description389
dc.languageen
dc.publisherMunksgaard Int Publ Ltd
dc.publisherCopenhagen
dc.publisherDinamarca
dc.relationJournal Of Periodontal Research
dc.relationJ. Periodont. Res.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectcyclosporin A
dc.subjectgingival overgrowth
dc.subjectregression
dc.subjectmorphometry
dc.subjectTransplant Patients
dc.subjectTissues
dc.subjectDrug
dc.titleMorphometric evaluation of gingival overgrowth and regression caused by cyclosporin in rats
dc.typeArtículos de revistas


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