Artículos de revistas
Salivary cortisol concentrations, stress and quality of life in women with endometriosis and chronic pelvic pain
Registro en:
Stress-the International Journal On The Biology Of Stress. Informa Healthcare, v. 11, n. 5, n. 390, n. 397, 2008.
1025-3890
WOS:000259315000007
10.1080/10253890701840610
Autor
Petrelluzzi, KFS
Garcia, MC
Petta, CA
Grassi-Kassisse, DM
Spadari-Bratfisch, RC
Institución
Resumen
The objective of this study was to evaluate the perceived stress index, quality of life, and hypothalamus-pituitary-adrenal axis activity in women with endometriosis and chronic pelvic pain. For the study, 93 women with endometriosis and 82 healthy women volunteered. The visual analogue scale (VAS) (0 = no pain; 10 = severe pain) was used to determine pain intensity; the perceived stress questionnaire (PSQ) defined stress index, and the health-related quality-of-life (HRQOL)-SF-36 questionnaire was used to evaluate quality of life. Salivary cortisol was measured at 0800, 1600, and 2000h and the awakening cortisol response was assessed to evaluate the hypothalamus-pituitary-adrenal axis activity. The results show that women with endometriosis and chronic pelvic pain of moderate intensity (4.1 +/- 0.58, mean +/- SEM) have higher levels of perceived stress (0.55 +/- 0.01 versus 0.42 +/- 0.01, p < 0.05), a poorer quality of life expressed as lower scores for all items of the inventory and hypocortisolism. Lower levels of salivary cortisol were observed in all three samples collected, as well as in the awakening cortisol response, for women with endometriosis (0.19 +/- 0.09 mu g/dl) when compared with controls (0.78 +/- 0.08 mu g/dl, p < 0.051), and it was independent of pain intensity and Mental health (MH) scores in SF-36. We concluded that women with endometriosis and chronic pelvic pain show low concentrations of salivary cortisol and a high level of perceived stress, associated with a poor quality of life. Whether the hypocortisolism was an adaptive response to the aversive symptoms of the disorder or a feature related to the etiology of endometriosis remains to be elucidated. 11 5 390 397 Foundation for the Support of Research in the State of Sao Paulo [03/09173-3] Improvement of University Level Personnel Foundation for the Support of Research in the State of Sao Paulo [03/09173-3]