Artículos de revistas
Diminished myelin-specific T cell activation associated with increase in CTLA4 and Fas molecules in multiple sclerosis patients treated with IFN-beta
Registro en:
Journal Of Interferon And Cytokine Research. Mary Ann Liebert Inc, v. 27, n. 10, n. 865, n. 873, 2007.
1079-9907
WOS:000250715100005
10.1089/jir.2007.0018
Autor
Hallal-Longo, DEM
Mirandola, SR
Oliveira, EC
Farias, AS
Pereira, FG
Metze, IL
Brandao, CO
Ruocco, HH
Damasceno, BP
Santos, LMB
Institución
Resumen
Multiple sclerosis (MS) is a chronic inflammatory disease of the white matter of the central nervous system (CNS) characterized by focal areas of demyelination. Interferon-beta (IFN-beta) provides an effective treatment that lessens the frequency and severity of exacerbations in relapsing-remitting multiple sclerosis (RRMS), but the mechanisms by which IFN-beta is efficient remain uncertain. The data presented here demonstrate that IFN-beta impairs the proliferative response to myelin basic protein (MBP) and myelin, as well as increasing the expression of the CTLA4 intracellular molecule. Moreover, this treatment increases the expression of surface Fas molecules and of the soluble form of these molecules. Our hypothesis is that the increase in Fas and CTLA4 molecules in MS patients may lead to lymphocyte apoptosis, which suggests possible mechanisms underlying the therapeutic response to IFN-beta. 27 10 865 873