Artículos de revistas
32 Factorial Design And Response Surface Analysis Optimization Of N-carboxybutylchitosan Synthesis
Registro en:
Carbohydrate Polymers. , v. 59, n. 1, p. 37 - 42, 2005.
1448617
10.1016/j.carbpol.2004.08.020
2-s2.0-10844294070
Autor
Dos Santos K.S.C.R.
Silva H.S.R.C.
Ferreira E.I.
Bruns R.E.
Institución
Resumen
A 32. factorial design investigation to optimize N-carboxybutylchitosan was carried out varying the levulinic acid/chitosan molar ratio between 1.00 and 3.00 and the sodium borohydride/chitosan molar ratio from 0.50 to 1.00. 1H NMR spectra signals at 1.0 and 2.5 ppm were used to monitor the reaction system. A quadratic model having significant terms for both molar ratios was found for N-carboxybutylchitosan substitution degree whereas a linear model best describes the substitution degree of 5-methylpyrrolidinone chitosan. Maximum N-carboxybutylchitosan and minimum 5-methylpyrrolidinone chitosan substitution degrees occur for levulinic acid/chitosan molar ratios between 2.00 and 3.00 and a 0.50 for sodium borohydride/chitosan molar ratio. © 2004 Elsevier Ltd. All rights reserved. 59 1 37 42 Agullo, E., Rodriguez, M.S., Ramos, V., Albertengo, L., Present and future role of chitin and chitosan in food (2003) Macromolecular Bioscience, 3 (10), pp. 521-530 Barros Neto, B.D., Scarminio, I.S., Bruns, R.E., (2002) Como Fazer Experimentos, , Campinas: Editora da Unicamp Biagini, G., Muzzarelli, R.A.A., Giardino, R., Castaldini, C., Biological materials for wound healing (1991) Chitin and Chitosan: Sources, Chemistry, Biochemistry, Physical Properties and Applications, pp. 16-24. , C. J. Brine, P. A. Sandford, J. P. Zikakis (Eds.), New York: Elsevier Box, G.E.P., Hunter, W.G., Hunter, J.S., (1978) Statistics for Experimenters: An Introduction to Design, Data Analysis and Model Building, , New York: Wiley Chirkov, S.N., The antiviral activity of chitosan (review) (2002) Applied Biochemistry and Microbiology, 38 (1), pp. 1-8 Duenas, M., Munduate, A., Perea, A., Irastorza, A., Exopoly-saccharide production by Pediococcus 2.6 in a semidefined médium under different growth conditions (2003) International Journal of Food Microbiology, 87 (1-2), pp. 113-120 Ilium, L., Chitosan and its use as a pharmaceutical excipient (1998) Pharmaceutical Research, 75 (9), pp. 1326-1331 Li, Q., Dunn, E.T., Grandmaison, E.W., Goosen, M.F.A., Applications and properties of chitosan (1997) Applications of Chitin and Chitosan, pp. 3-29. , M. F. A. Goosen (Ed.), Lancaster: Technomic Publishing Company Lim, S.H., Hudson, S.M., Review of chitosan and its derivatives as antimicrobial agents and their uses as textile chemicals (2003) Journal of Macromolecular Science-polymer Reviews, C43 (2), pp. 223-269 Morris, N.D., Mallouk, T.E., A high-throughput optical screening method for the optimization of colloidal water oxidation catalyst (2002) Journal of the American Chemical Society, 124 (31), pp. 11114-11121 Muzzarelli, R.A.A., Ilari, P., Tomasetti, M., Preparation and characteristic properties of 5-methyl pyrrolidinone chitosan (1993) Carbohydrate Polymers, 20 (2), pp. 99-105 Muzzarelli, R.A.A., Weckx, M., Filippini, O., Lough, C., Characteristic properties of N-carboxybutyl chitosan (1989) Carbohydrate Polymers, 11 (4), pp. 307-320 Rabea, E.I., Badawy, M.E.T., Stevens, C.V., Smagghe, G., Steurbaut, W., Chitosan as antimicrobial agent: Applications and mode of action (2003) Biomacromolecules, 4 (6), pp. 1457-1465 Ravi Kumar, M.N.V., A review of chitin and chitosan applications (2000) Réactive and Functional Polymers, 46 (1), pp. 1-27 Rinaudo, M., Desbrières, J., Le Dung, P., Thuy Binh, P., Dong, N.T., NMR investigation of chitosan derivatives formed by the reaction of chitosan with levulinic acid (2001) Carbohydrate Polymers, 46 (4), pp. 339-348 Shigemasa, Y., Matsuura, H., Sashiwa, H., Saimoto, H., Evaluation of different absorbance ratios from infrared spectroscopy for analyzing the degree of deacetylation in chitin (1996) International Journal of Biological Macromolecules, 75 (3), pp. 237-242 Singla, A.K., Chawla, M., Chitosan: Some pharmaceutical and biological aspects - An update (2001) Journal of Pharmacy and Pharmacology, 55 (8), pp. 1047-1067 Tagliabue, M., Carluccio, L.C., Ghisletti, D., Perego, C., Multivariate approach to zeolite synthesis (2003) Catalysis Today, 81 (3), pp. 405-412