Artículos de revistas
Abnormal Production Of Transforming Growth Factor β And Interferon γ By Peripheral Blood Cells Of Patients With Multidrug-resistant Pulmonary Tuberculosis In Brazil
Registro en:
Journal Of Infection. , v. 51, n. 4, p. 318 - 324, 2005.
1634453
10.1016/j.jinf.2004.08.035
2-s2.0-28044467549
Autor
Castro A.Z.
Diaz-Bardalez B.M.
Oliveira E.C.
Garcia R.C.
Afiune J.B.
Paschoal I.A.
Santos L.M.B.
Institución
Resumen
Objective. The aim of the present study was to determine the immune response profile that differentiates patients with newly diagnosed (non-treated) pulmonary tuberculosis from multidrug-resistant (MDR) ones, as well as from healthy, tuberculin positive individuals. Methods. Lymphocytes proliferative response to non-specific mitogen (PHA) and PPD were evaluated by 3H thymidine incorporation and cytokines were quantified using an ELISA assay. Results. Patients with active disease showed a diminished proliferative response to PHA and PPD, while multidrug-resistant patients showed a diminished proliferative response to PHA, but a normal response to PPD. The cytokine production of newly diagnosed patients was characterized by a diminished production of IFNγ and normal production of transforming growth factor (TGFβ), while MDR patients revealed a normal production of IFNγ accompanied by an increase in TGFβ. Conclusions. 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