Artículos de revistas
Steroid-induced Cataracts In Patients With Autoinmune Hepatitis
Acta Gastroenterologica Latinoamericana. , v. 33, n. 2, p. 93 - 97, 2003.
De Tommaso A.M.A.
Santos Daniela S.M.
Background: Posterior subcapsular cataract (PSC) has been reported in patients on corticosteroids therapy for various pathologies. Autoimmune hepatitis (AIH) is a progressive inflammatory hepatic disease for which corticosteroids are recommended but PSC has not yet been reported in AIH patients on corticosteroids therapy. Methods: The AIH patients at our service underwent an ophthalmological assessment and their files were analyzed establish the dosage and duration of medication, the presence of visual complaints and the type of AIH, in order to correlate these with the ophthalmological findings. Patients were examined with a slit lamp following pupil dilation. Results: 17 AIH patients evaluated, only one patient had PSC. Conclusion: Although the frequency of PSC was low (1/17) in AIH patients on costicosteroid therapy, these individuals should undergo occasional ophthalmological assessment for the presence of cataracts since their visual acuity and quality of life may be adversely affected.3329397Vaughan, D., Cristalino (1997) Oftalmologia Geral, pp. 117-125. , Vaughan D & Asbury T, ed. D. da Universidade de São PauloSaxby, L.A., Basic Science of the Lens: Biophysics (1999) Ophtalmology, pp. 431-434. , Yanoff M & Duker JS, ed. Mosby International LtdGans, L.A., Cobo, L.M., Johns, K.J., Lens and Cataract (1995) Basic and Clinical Science Course, pp. 48-54. , American Academy of OphthalmologyCrew, S.J., Posterior subcapsular lens opacities in patients on long-term corticosteroid therapy (1963) Br Med J, 1, pp. 1644-1647Chylac, L.T., Leske, C., McCarthy, D., Lens Opacities Classification System II (LOCS II) (1989) Arch Ophthalmol, 107, pp. 991-997Chitkara, D.K., Cataract: Cataract Formation Mechanisms (1999) Ophtalmology, pp. 481-488. , Yanoff M & Duker JS, ed. Mosby International LtdBlack, R.L., Oglesby, R.B., Von Sallman, L., Posterior subcapsular cataracts induced by corticosteroids in patients with rheumatoid arthritis (1960) JAMA, 174, pp. 166-171Skalka, H.W., Prchal, J.T., Effect of corticosteroids on cataract formation (1980) Arch Ophthalmol, 98, pp. 1773-1777Fournier, C., Millot, J.Á., Clermont, M.J., The concept of corticosteroid caractogenic factor revised (1990) Can J Ophthalmol, 25, pp. 345-347Limaye, S.R., Pillai, S., Tina, L.U., Relationship of steroid dose to degree of posterior subcapsular cataracts in nephrotic syndrome (1988) Ann Ophthalmol, 20, pp. 225-227Majure, M., Mroueh, S., Spock, A., Risk factors for the development of posterior subcapsular cataracts in patients with cystic fibrosis and allergic bronchopulmonary aspergillosis treated with corticosteroids (1989) Pediatr Pulmonol, 6, pp. 260-262Tripathi, R.C., Kipp, M.A., Kirschner, B.S., Ocular toxicity of prednisone in pediatric patients with inflammatory bowel disease (1992) Lens Eye Toxic Res, 9, pp. 469-482Rooklin, A.R., Lampert, S.I., Jaeger, E.A., Posterior subcapsular cataracts in steroid-requiring asthmatic children (1979) J Allergy Clin Immunol, 63, pp. 383-386Kanski, J.J., Disorders of the Lens (1996) Clinical Ophtalmology, pp. 285-309. , Kanski JJ, ed. Butterworth- HeinemannBarenholtz, H., Effect of inhaled corticosteroids on the risk of cataract formation in patients with steroid-dependent asthma (1996) Ann Pharmacother, 30, pp. 1324-1327Cumming, R.G., Mitchell, P., Leeder, S.R., Use of inhaled cortcosteroids and the risk of cataracts (1997) N Engl J Med, 337, pp. 8-14Kuna, P., Longterm effects of steroid therapy (1998) Wiad Lek, 51 (1 SUPPL.), pp. 12-18Kaye, L.D., Kalenak, J.W., Price, R.L., Ocular implications of long-term prednisone therapy in children (1993) J Pediatr Ophthalmol Strabismus, 30, pp. 142-144Kollarits, C.R., Swann, E.R., Shapiro, R.S., HLA-A1 and steroid-induced cataracts in Renal transplant patients (1982) Ann Ophthalmol, 14, pp. 1116-1118Adhikary, H.P., Sells, R.A., Basu, P.K., Ocular complications of systemic steroid after renal transplantation and their association with HLA (1982) Br J Ophthalmol, 66, pp. 290-291Miura, H., Hepatite auto-imune (1995) Rev Paul Pediatria, 13, pp. 120-122Johnson, P.J., McFarlane, I.G., Meeting Report - International Autoimmune Hepatitis Group (1993) Hepatology, 18, pp. 998-1005Alvarez, F., Berg, P.A., Bianchi, F.B., Internacional Autoimmune Hepatitis Group Report: Review of criteria for diagnosis of autoimmune hepatitis (1999) J Hepatol, 31, pp. 929-938Alagille, D., Chronic hepatitis (1995) Pediatric Clinical Gastroenterology, pp. 712-720. , Roy CC, Silverman A and Alagille D, ed. St. Louis: Missouri