Actas de congresos
Biomarkers Of Exposure To Lead [biomarcador De E Exposição A Chumbo]
Registro en:
Medicina. , v. 42, n. 3, p. 291 - 300, 2009.
766046
2-s2.0-77949860911
Autor
Gerlach R.F.
Goncalves S.C.D.
Guerra C.D.S.
Institución
Resumen
This article aims at describing some of the most important biomarkers of exposure to lead, showing its advantages and limitations, as well as how they relate to present, past or cumulative exposure to lead. This basic knowledge is essential for the comprehension of the effects of lead, the difficulties of the diagnosis of excessive exposure, and the problem of exposure to low levels of lead. The biomarkers of exposure discussed in depth in this article are blood, bone, and teeth. 42 3 291 300 Barbosa Jr, F., Tanus-Santos, J.E., Gerlach, R.F., Parsons, J.P., A critical review of biomarkers used for monitoring human exposure to lead: Advantages, limitations, and future needs (2005) Environ Health Perspect, 113, pp. 1669-1674 Bergdahl, I.A., Skerfving, S., Biomonitoring of lead exposure - alternatives to blood (2008) J Toxicol Environ Health, 71, pp. 1235-1243 Parsons, P.J., Reilly, A.A., Hussain, A., Observational study of erythrocyte protoporphyrin screening test for detecting low lead exposure in children: Impact of lowering the blood lead action threshold (1991) Clin Chem, 37, pp. 216-225 Hu, H., Shih, R., Rothemberg, S., Schwartz, B.S., The epidemiology of lead toxicity in Adults: Measuring dose and consideration of other methodologic issues (2007) Environ Health Perspect, 115, pp. 455-462 Parsons, P.J., Slavin, W., A rapid Zeeman graphite furnace atomic absorption spectrometric method for the determination of lead in blood (1993) Spectrochim Acta, B, 48, pp. 925-939 Esernio-Jenssen, D., Busch, V., Parsons, J.P., Evaluation of VACUTAINER PLUS Low Lead Tubes for blood lead and erythrocyte protophorphirin testing (1999) Clin Chem, 45, pp. 148-150 Parsons, P.J., Reilly, A.A., Esernio-Jenssen, D., Screening children exposed to lead: An assesment of the capilarry blood lead fingerstick test (1997) Clin Chem, 43, pp. 302-311 O'Flaherty, E.J., Physiologically based models for bone-seeking elements. V: Lead absorption and disposition in children (1995) Toxicol Appl Pharmacol, 131, pp. 297-308 Rabinowitz, M.B., Wetherill, G.W., Koopple, J.D., Kinetic analysis of lead metabolism in healthy humans (1976) J Clin Invest, 58, pp. 260-270 Roels, H., Konings, J., Green, S., Bradley, D., Chettle, D., Lauwerys, R., Time-integrated blood lead concentration is a valid surrogate for estimating the cumulative lead dose assessed by tibial lead measurement (1995) Environ Res, 69, pp. 75-82 Shih, R.A., Hu, H., Weisskopf, M., Schwartz, B.S., Cumulative lead dose and cognitive function in adults : A review of studies that measured both blood and bone lead (2007) Environ Health Perspect, 115, pp. 483-492 Navas-Acien, A., Gualler, E., Silbergeld, E.K., Rothemberg, S.J., Lead exposure and cardiovascular disease - a systematic review (2007) Environ Health Perspect, 115, pp. 472-482 Schwartz, B.S., Hu, H., Adult lead exposure: Time for change (2007) Environ Health Perspect, 115, pp. 451-454 Hu, H., Rabinowitz, M., Smith, D., Bone lead as a biological marker in epidemiologic studies of chronic toxicity: Conceptual paradigms (1998) Environ Health Perspect, 106, pp. 1-8 Todd, A.C., Chettle, D.R., In vivo X-ray fluorescence of lead in bone: Review and current issues (1994) Environ Health Perspect, 102, pp. 172-177 Nie H, Chettle D, Luo L, O'Meara J. Dosimetry study for a new in vivo X-ray fluorescence (XRF) bone lead measurement system. Nucl Instr and Meth in Phys Res. B 2007 263: 225-30Aro, A., Amarasiriwardena, C., Lee, M.L., Kim, R., Hu, H., Validation of K x-ray fluorescence bone lead measurements by inductively coupled plasma mass spectrometry in cadaver legs (2000) Med Phys, 27, pp. 119-123 Ahmed, N., Fleming, D.E.B., Wilkie, D., O'Meara, J.M., Effects of overlying soft tissue on X-ray fluorescence bone lead measurement uncertainty (2006) Radiation Physics and Chemistry, 75, pp. 1-6 Nanci, A., Histologia oral de Ten Cate: Desenvolvimento, estrutura e função (2008) 7aEd, , Rio de Janeiro RJ, Elsevier; Needleman, H.L., Gunnoe, C., Leviton, A., Reed, R., Peresie, H., Maher, C., Barret, P., Deficits in psychologic and classroom performance of children with elevated dentine lead levels (1979) N Engl J Med, 300, pp. 689-695 Hansen, O.N., Trillingsgaard, A., Beese, I., Lyngbye, T., Grandjean, P., A neuropsychological study of children with elevated dentine lead level: Assessment of the effect of lead in different eosio-economic groups (1989) Neurotoxicol Teratol, 11, pp. 205-213 Canfield, R.L., Henderson, C.R.J., Cory-Slechta, D.A., Cox, C., Jusko, T.A., Lanphear, B.P., Intellectual impairment in children with blood lead concentrations below 10 μg per deciliter (2003) N Engl J Med, 348, pp. 1517-1526 Avery, J.K., (2002) Oral development and histology, , ed, assoc. ed, Third Edition, Thieme, New York Grandjean, P., Jorgensen, P.J., Retention of lead and cadmium in prehistoric and modern human teeth (1990) Environ Res, 53, pp. 6-15 Dean, M.C., Tooth microsctructure tracks the pace of human life-history evolution (2006) Proc R Microsc Soc. B, 273, pp. 2799-2808 Needleman, H.L., Tuncay, O.C., Shapiro, I.M., Lead levels in deciduous teeth of urban and suburban American children (1972) Nature (Lond.), 235, pp. 111-112 Gerlach RF, Line SRP. Ameloblastos. In: Carvalho HF, Collares-Buzato CB (editores). Células: uma abordagem multidisciplinar. 1a ed. Barueri (SP): Manole 2005. p. 95-106Smith, C.E., Cellular and chemical events during enamel maturation (1998) Crit Rev Oral Biol Med, 9, pp. 128-136 Brudevold, F., Steadman, L.T., The distribution of lead in human enamel (1956) J Dent Res, 35, p. 43 Cleymaet, R., Retief, D.H., Quartier, E., Slop, D., Coomans, D., Michotte, Y., A comparative study of the lead and cadmium content of surface enamel of Belgian and Kenyan children (1991) Sci Total Environ. A, 104, pp. 175-189 Robinson, C., Kirkham, J., Brookes, S.J., Roger, C.S., Chemistry of mature enamel (Chapter 8) (1995) Dental enamel: Formation to destruction, , Robinson C, Kirkham J, Shore R eds, 1st ed. London, CRC Press Cleymaet, R., Quartier, E., Slop, D., Retief, D.H., Smeyers-Verbeke, J., Coomans, D., Model for assessment of lead content in human surface enamel (1991) J Toxicol Environ Health. B, 32, pp. 111-127 Cleymaet, R., Bottenberg, P., Retief, D.H., Slop, D., Michotte, Y., Coomans, D., In vivo use of a dual acid etch biopsy for the evaluation of lead profiles in human surface enamel (1991) Caries Res, 25, pp. 256-263 Cleymaet, R., Collys, K., Retief, D.H., Michotte, Y., Slop, D., Taghon, E., Maex, W., Coomans, Relation between lead in surface tooth enamel, blood, and saliva from children residing in the vicinity of a non-ferrous metal plant in Belgium (1991) Br J Ind Med, 48, pp. 702-709 Gomes, V.E., Sousa, M.L.R., Barbosa, F., Krug, F.J., Saraiva, M.C.P., Cury, J.A., Gerlach, R.F., In vivo studies on lead content of de ciduous teeth superficial enamel of pre-school children (2004) Sci Total Environ, 320, pp. 25-35 Costa de Almeida GR, Pereira Saraiva Mda C, Barbosa F Jr, Krug FJ, Cury JA, Rosário de Sousa M da L, Rabelo Buzalaf MA, Gerlach RF. Lead contents in the surface enamel of deciduous teeth sampled in vivo from children in uncontaminated and in lead-contaminated areas. Environ Res. 2007 104: 337-45Costa de Almeida, G.R., Molina, G.F., Meschiari, C.A., Barbosa de Sousa, F., Gerlach, R.F., Analysis of enamel microbiopsies in shed primary teeth by Scanning Electron Microscopy (SEM) and Polarizing Microscopy (PM) (2009) Sci Total Environ, 407, pp. 5169-5175 Brudevold, F., Redá, A., Aasenden, R., Bakhos, Y., Determination of trace elements in surface enamel of human teeth by a new biopsy procedure (1975) Arch Oral Biol, 20, pp. 667-673 De Almeida, G.R., de Souza, Guerra, C., Tanus-Santos, J.E., FJr, B., Gerlach, R.F., A plateau detected in lead accumulation in subsurface deciduous enamel from individuals exposed to lead may be useful to identify children and regions exposed to higher levels of lead (2008) Environ Res, 107, pp. 264-270 Costa de Almeida, GR. Utilização de biomarcadores de dose interna para avaliação da exposição ao chumbo e suas correlações com anemia e polimorfismos genéticos em crianças residentes em uma região supostamente não contaminada. [Tese de Doutorado]. Campinas: Universidade Estadual de Campinas, 2009Costa de Almeida, G.R., de Freitas Tavares, C.F., de Souza, A.M., Sampaio de Sousa, T., Rodrigues Funayama, C.A., Barbosa Jr, F., Tanus-Santos, J.E., Gerlach, R.F., Whole blood, serum, and saliva lead concentrations in 6- to 8-year-old children (2010) Sci Total Environ, (408), pp. 1551-1556