Artículos de revistas
High Frequency Of Vitamin B12 Deficiency In A Brazilian Population
Registro en:
Public Health Nutrition. , v. 13, n. 8, p. 1191 - 1197, 2010.
13689800
10.1017/S1368980009992205
2-s2.0-77957242128
Autor
Xavier J.M.
Costa F.F.
Annichino-Bizzacchi J.M.
Saad S.T.O.
Institución
Resumen
Objective: There are few studies regarding vitamin B12 deficiency in developing countries. In Brazil, a late diagnosis of vitamin B12 deficiency progressing to severe neurological damage is common. Thus, the aim of the present study was to verify the frequency of vitamin B 12 deficiency in two Brazilian populations (elderly and adult participants) and to compare different methods of vitamin B12 deficiency detection. Design: Five hundred participants were recruited from health centres from south-east Brazil and were separated into two groups: 60 years old or more and 30-59 years old. Vitamin B12 and folate concentrations were measured using electrochemiluminescence immunoassay (ECI) and RIA. Methylmalonic acid (MMA) was measured by LC coupled to tandem MS. Full blood counts were acquired using standard methods. Results: All participants had normal blood count results and mean cell volume less than 99 fl; none of them presented folate deficiency according to the results, which were all greater than 3 ng/ml. Cobalamin levels less than 200 pmol/l were identified by one of the two or by both methods in 7.2 % of the participants aged 60 years or more and 6.4 % of the participants aged 30-59 years. MMA levels were higher in older subjects (P = 0.007) compared with younger subjects. A greater correlation of MMA v. RIA was observed than of MMA v. ECI (P = 0.0017 v. P = 0.014). MMA quantification estimated that cobalamin deficiency was present in more than 11 % of the subjects for both studied groups. Conclusions: The study shows that vitamin B12 deficiency is frequent in Brazilian adults and suggests that RIA is more sensitive than ECl for measuring cobalamin levels. Copyright © 2010 The Authors. 13 8 1191 1197 Hin, H., Clarke, R., Sherliker, P., Clinical relevance of low serum vitamin B12 concentrations in older people: The Banbury B12 study (2006) Age Ageing, 35, pp. 416-422 Clarke, R., Refsum, H., Birks, J., Screening for vitamin B-12 and folate deficiency in older persons (2003) Am J Clin Nutr, 77, pp. 1241-1247 Cuskelly, G.J., Mooney, K.M., Young, I.S., Folate and vitamin B12: Friendly or enemy nutrients for the elderly (2007) Proc Nutr Soc, 66, pp. 548-558 Masnou, H., Domenech, E., Navarro-Llavat, M., Pernicious anaemia in triplets. A case report and literature review (2007) Gastroenterol Hepatol, 30, pp. 580-582 Solomon, L.R., Cobalamin-responsive disorders in the ambulatory care setting: Unreliability of cobalamin, methylmalonic acid, and homocysteine testing (2005) Blood, 105, pp. 978-985 Lewerin, C., Matousek, M., Steen, G., Significant correlations of plasma homocysteine and serum methylmalonic acid with movement and cognitive performance in elderly subjects but no improvement from short-term vitamin therapy: A placebo-controlled randomized study (2005) Am J Clin Nutr, 81, pp. 1155-1162 Stabler, S.P., Allen, R.H., Vitamin B12 deficiency as a worldwide problem (2004) Annu Rev Nutr, 24, pp. 299-326 Clarke, R., Sherliker, P., Hin, H., Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin (2007) Clin Chem, 53, pp. 963-970 Raman, G., Tatsioni, A., Chung, M., Heterogeneity and lack of good quality studies limit association between folate, vitamins B-6 and B-12, and cognitive function (2007) J Nutr, 137, pp. 1789-1794 Fora, M.A., Mohammad, M.A., High frequency of suboptimal serum vitamin B12 level in adults in Jordan (2005) Saudi Med J, 26, pp. 1591-1595 VanderJagt, D.J., Spelman, K., Ambe, J., Folate and vitamin B12 status of adolescent girls in northern Nigeria (2000) J Natl Med Assoc, 92, pp. 334-340 Green, R., Unreliability of current assays to detect cobalamin deficiency: 'Nothing gold can stay' (2005) Blood, 105, p. 910 Kumar, S., Ghosh, K., Das, K.C., Serum vitamin B12 levels in an Indian population: An evaluation of three assay methods (1989) Med Lab Sci, 46, pp. 120-126