Artículos de revistas
Production Optimization With Operating Constraints For A Fed-batch Reactor With Dmc Predictive Control
Registro en:
Chemical Engineering Science. Elsevier Science Ltd, Exeter, United Kingdom, v. 54, n. 13-14, p. 2745 - 2751, 1999.
92509
10.1016/S0009-2509(98)00442-4
2-s2.0-0033166489
Autor
Rodrigues J.A.D.
Maciel Filho R.
Institución
Resumen
This work presents a production optimization approach with operating constraints applied to a fed-batch penicillin process with a DMC predictive controller. A deterministic and non-structured mathematical model of the fed-batch penicillin production process solved by a fourth order variable step Runge-Kutta-Gill algorithm type simulated the system. The production process optimization has been performed through the manipulation of the initial cell and the substrate fed-batch concentrations besides the fed-batch flow rate strategy. In order to carry out this procedure it was necessary to compute a production index that considers product amount and process operating constraints such as cell, substrate and dissolved oxygen concentrations besides the bioreactor final volume through the penalty functions concept. The optimization algorithm was based on the modified simplex method. The DMC control algorithm was implemented in order to stabilize the dissolved oxygen concentration through the agitation speed manipulation. This controller was found to be appropriate to work coupled with a optimization procedure due to the fact that it gives a smooth behavior to this critical constraint even with all disturbs during the convergence.This work presents a production optimization approach with operating constraints applied to a fed-batch penicillin process with a DMC predictive controller. A deterministic and non-structured mathematical model of the fed-batch penicillin production process solved by a fourth order variable step Runge-Kutta-Gill algorithm type simulated the system. The production process optimization has been performed through the manipulation of the initial cell and the substrate fed-batch concentrations besides the fed-batch flow rate strategy. In order to carry out this procedure it was necessary to compute a production index that considers product amount and process operating constraints such as cell, substrate and dissolved oxygen concentrations besides the bioreactor final volume through the penalty functions concept. The optimization algorithm was based on the modified simplex method. The DMC control algorithm was implemented in order to stabilize the dissolved oxygen concentration through the agitation speed manipulation. This controller was found to be appropriate to work coupled with a optimization procedure due to the fact that it gives a smooth behavior to this critical constraint even with all disturbs during the convergence. 54 13-14 2745 2751 Edgar, T.F., Himmelblau, D.M., (1989) Optimization of Chemical Process, , New York: McGraw Hill Hersbach, G.J.M., The penicillins: Properties, biosynthesis, and fermentation (1984) Biotechnology of IndusTrial Antibiotics, , E.J. Vandamme (Ed.), New York: Marcel Dekker Lim, H.C., Tayeb, Y.J., Modak, J.M., Bonte, P., Computational algorithms for optimal feed rates for a class of fed batch fermentation: Numerical results for penicillin and cell mass production (1986) Biotechnol. Bioeng, 28, pp. 1408-1420 Luus, R., Optimization of fed batch fermentations by iterative dynamic programming (1993) Biotechnol. Bioengng, 41, pp. 599-602 Marchetti, J.L., Mellichamp, D.A., Seborg, D.E., Predictive control based on discrete convolutions models (1983) Ind. Engng Chem. Process Design Dev., 22, pp. 488-495 Rodrigues, J.A.D., Maciel Filho, R., Optimal feed rates strategies with operating constraints for the penicillin production process (1996) Chem Engng Sci., 51, pp. 2859-2864 Rodrigues, J.A.D., Maciel Filho, R., Production phase sensitivity analysis of the penicillin process by factorial design (1996) Brazilian J. Chem. Engng, 13, pp. 107-115 Rodrigues, J.A.D., Maciel Filho, R., Response surface methodology as a toll for DMC design: Application for feed-batch bioreactor (1997) Proceedings of the 1st European Congress on Chemical Engineering, 4, pp. 2599-2602 San, K.Y., Stephanopoulos, G., Optimization of fed batch penicillin fermentation: A case of singular optimal control with state constraints (1989) Biotechnol. Bioengng, 34, pp. 72-78 Shimizu, K., An overview on the control system design of bioreactors (1993) Adv. Biochem. Engng Biotechnol., 50, pp. 65-84 Smith, J.J., Lilly, M.D., Fox, R.I., The effect of agitation on the morphology and penicillin production of Penicillium chrysogenum (1990) Biotechnol. Bioengng, 35, pp. 1011-1023