Artículos de revistas
Monitoring And Control Of Coating And Granulation Processes In Fluidized Beds - A Review
Registro en:
Advanced Powder Technology. Elsevier, v. 25, n. 1, p. 195 - 210, 2014.
9218831
10.1016/j.apt.2013.04.008
2-s2.0-84896389348
Autor
Da Silva C.A.M.
Butzge Jr. J.
Nitz M.
Taranto O.P.
Institución
Resumen
This review presents a compilation of works of the main techniques for monitoring and control fluidization regimes, particle size and moisture content during coating and granulation processes in the fluidized bed. The development of monitoring and control systems for coating and granulation of particles is highly desirable, not only to allow the operation in a stable bubbling fluidization regime, which intensifies heat and mass transfer, but also to ensure strict quality specifications for products, such as, uniform particle size distribution, low moisture content and good flowability. This paper focuses on the discussion of methods used and results obtained in studies on monitoring and control of granulation and coating process in the fluidized bed reported in the literature in the last decades. Pressure fluctuation signal analysis is widely discussed as a tool of regime monitoring. To monitor particle size, techniques such as, Near Infrared spectroscopy (NIR), Focused Beam Reflectance Measurements (FBRMs), among others are presented in detail. As for moisture content tracking, the methods are reviewed like acoustic signals, capacitance, microwave resonance and spectroscopy. It is evident that although these processes are highly complex, the techniques presented here have evolved mainly due to the efforts of several research groups, showing great potential for applications in industry, emphasizing the importance of this research field. © 2013 The Society of Powder Technology Japan. Published by Elsevier B.V. 25 1 195 210 Lipsanen, T., Närvänen, T., Räikkönen, H., Antikainen, O., Yliruusi, J., Particle size, moisture, and fluidization variations described by indirect in-line physical measurements of fluid bed granulation (2008) AAPS PharmSciTech, 9, pp. 1070-1077 Lipsanen, T., Process analytical technology approach on fluid bed granulation and drying (2008) Identifying Critical Relationships and Constructing the Design Space, p. 51. , Academic Dissertation - Faculty of Pharmacy of the University of Helsinki, Finland, 2008 Maronga, S., (1998) On the Optimization of the Fluidized Bed Particulate Coating Process, p. 78. , Ph.D. Thesis - Department of Chemical Engineering and Technology - Royal Institute of Technology, Stockholm Johnsson, F., Zijerveld, R.C., Schouten, J.C., Van Der Beek, C.M., Leckner, B., Characterization of fluidization regimes by time-series analysis of pressure fluctuations (2000) International Journal of Multiphase Flow, 26, pp. 663-715 Halstensen, M., De Bakker, P., Esbensen, K.H., Acoustic chemometric monitoring of an industrial granulation production process-a PAT feasibility study (2006) Chemometrics and Intelligent Laboratory Systems, 84 (1-2 SPEC. ISS.), pp. 88-97. , DOI 10.1016/j.chemolab.2006.05.012, PII S0169743906001134 Naelapaa, K., Veski, P., Pedersen, J.G., Anov, D., Jorgensen, P., Kristensen, H.G., Bertelsen, P., Acoustic monitoring of a fluidized bed coating process (2007) International Journal of Pharmaceutics, 332 (1-2), pp. 90-97. , DOI 10.1016/j.ijpharm.2006.09.036, PII S0378517306007885 Wang, J., Ren, C., Yang, Y., Hou, L., Characterization of particle fluidization pattern in a gas solid fluidized bed based on acoustic emission (AE) measurement (2009) Industrial & Engineering Chemistry Research, 48, pp. 8508-8514 Schouten, J.C., Van Den Bleek, C.M., Monitoring the quality of fluidization using the short-term predictability of pressure fluctuations (1998) AIChE Journal, 44 (1), pp. 48-60 Van Ommen, J.R., De Korte, R.J., Van Den Bleek, C.M., Rapid detection of defluidization using the standard deviation of pressure fluctuations (2004) Chemical Engineering and Processing, 43, pp. 1329-1335 Chirone, R., Miccio, F., Scala, F., Mechanism and prediction of bed agglomeration during fluidized bed combustion of a biomass fuel: Effect of the reactor scale (2006) Chemical Engineering Journal, 123 (3), pp. 71-80. , DOI 10.1016/j.cej.2006.07.004, PII S1385894706002956 Nijenhuis, J., Korbee, R., Lensselink, J., Kiel, J.H.A., Van Ommen, J.R., A method for agglomeration detection and control in full-scale biomass fired fluidized beds (2007) Chemical Engineering Science, 62 (1-2), pp. 644-654. , DOI 10.1016/j.ces.2006.09.041, PII S0009250906006105, Fluidized Bed Applications Bartels, M., Lin, W., Nijenhuis, J., Kapteijn, F., Van Ommen, J.R., Agglomeration in fluidized beds at high temperatures: Mechanisms, detection and prevention (2008) Progress in Energy and Combustion Science, 34, pp. 633-666 Bartels, M., Nijenhuis, J., Kapteijn, F., Van Ommen, J.R., Detection of agglomeration and gradual particle size changes in circulating fluidized beds (2010) Powder Technology, 202, pp. 24-38 Briens, C., McDougall, S., Chan, E., On-line detection of bed fluidity in a fluidized bed coker (2003) Powder Technology, 138 (2-3), pp. 160-168. , DOI 10.1016/j.powtec.2003.09.012 Talu, I., Tardos, G.I., Ruud Van Ommen, J., Use of stress fluctuations to monitor wet granulation of powders (2001) Powder Technology, 117 (1-2), pp. 149-162. , DOI 10.1016/S0032-5910(01)00321-7, PII S0032591001003217 Chaplin, G., Pugsley, T., Winters, C., Monitoring the fluidized bed granulation process based on s-statistic analysis of a pressure time series (2005) AAPS PharmSciTech, 6 (2), pp. 198-201 Parise, M.R., Silva, C.A.M., Ramazini, M.J., Taranto, O.P., Identification of defluidization in fluidized bed coating using the Gaussian spectral pressure distribution (2011) Powder Technology, 206, pp. 149-153 Silva, C.A.M., Parise, M.R., Silva, F.V., Taranto, O.P., Control of fluidized bed coating particles using Gaussian spectral pressure distribution (2011) Powder Technology, 212, pp. 445-458 Nunes, J.F., Silva, C.A.M., Moris, V.A.S., Rocha, S.C.S., Taranto, O.P., Spectral analysis of pressure drop fluctuation in vibrofluidized bed coating (2011) Chemical Engineering Transactions, 24, pp. 649-654 De Martín, L., Van Den Dries, K., Van Ommen, J.R., Comparison of three different methodologies of pressure signal processing to monitor fluidized-bed dryers/granulators (2011) Chemical Engineering Journal, 172, pp. 487-499 Van Ommen, J.R., Sasic, S., Van Der Schaaf, J., Gheorghiu, S., Johnsson, F., Coppens, M.O., Time-series analysis of pressure fluctuations in gas-solid fluidized beds - A review (2011) International Journal of Multiphase Flow, 37, pp. 403-428 Silva, O.S., Rocha, S.C.S., Marsal, S.C., The influence of the moisture content of microcrystalline cellulose on the coating process in a fluidized bed (2004) Brazilian Journal of Chemical Engineering, 2, pp. 325-333 El Mafadi, S., Hayert, M., Poncelet, D., Fluidization control in Wuster coating process (2003) Hemijska Industrija, 57, pp. 641-644 Poncelet, D., Prata, A.S., El Mafadi, S., Boilleraux, L., Optimisation and process control of fluid bed coating (2009) 17th International Conference on Bioencapsulation, , Groningen, Netherlands, September 24-26 Maudhuit, A., Boillereaux, L., El Mafadi, S., Poncelet, D., Development of process-control for coating in fluid bed (2010) 18th International Conference on Bioencapsulation, , Porto, Portugal, October 1-2 Terashita, K., Watano, S., Miyanami, K., Determination of end-point by frequency analysis of power consumption in agitation granulation (1990) Chemical and Pharmaceutical Bulletin, 38, pp. 3120-3123 Watano, S., Terashita, K., Miyanami, K., Analysis of granulation process and determination of operational end point in a tumbling fluidized bed granulation (1993) Bulletin of University of Osaka Prefecture. Series A, 41, pp. 47-56 Watano, S., Tanaka, T., Miyanami, K., A method for process monitoring and determination of operational end-point of consumption in agitation granulation (1995) Advanced Powder Technology, 6, pp. 91-102 Diks, C., Van Zwet, W.R., Takens, F., DeGoede, J., Detecting differences between delay vector distributions (1996) Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics, 53 (3), pp. 2169-2176 Park, J., Kim, J., Cho, S.H., Han, K.H., Yi, C.K., Jin, G.T., Development of sorbent manufacturing technology by agitation fluidized bed granulator (AFBG) (1999) Korean Journal of Chemical Engineering, 16, pp. 659-663 Moris, V.A.S., Visnadi, C.B., Cunha, R.L.G., Rocha, S.C.S., Taranto, O.P., Monitoring of fluidized bed coating process of microcrystalline cellulose XXXII Congresso Brasileiro de Sistemas Particulados, , Maringá, Paraná, Brazil, October 22-25, 2006 (in Portuguese) Visnadi, C.B., Moris, V.A.S., Cunha, R.L.G., Rocha, S.C.S., Taranto, O.P., Monitoring of modified fluidized bed granulation process of microcrystalline cellulose XXXIII Congresso Brasileiro de Sistemas Particulados, , Aracaju, Sergipe, Brazil, October 16-19, 2007 (in Portuguese) Parise, M.R., Taranto, O.P., Kurka, P.R.G., Benetti, L.B., Detection of the minimum gas velocity region using Gaussian spectral pressure distribution in a gas-solid fluidized bed (2008) Powder Technology, 182 (3), pp. 453-458. , DOI 10.1016/j.powtec.2007.07.014, PII S0032591007003567 Parise, M.R., (2007) Application of the Normal Spectral Distribution in A Gas-solid Fluidized Bed, p. 109. , PhD. Thesis. School of Chemical Engineering, University State of Campinas, Campinas, 2007 Silva, C.A.M., Parise, M.R., Ramazini, M.J., Taranto, O.P., Study of defluidization of wet particle in a fluidized bed using Gaussian spectral analysis (2009) Proceedings of 8th World Congress of Chemical Engineering, , Montreal, Canada, August 23-27 Silva, C.A.M., (2009) Application of the Gaussian Spectral Analysis Methodology to Monitor and Control the Defluidization in the Particles Coating Process, p. 145. , Master's Dissertation, School of Chemical Engineering, University State of Campinas, Campinas, 2009 Silva, C.A.M., Parise, M.R., Taranto, O.P., Monitoring of defluidization phenomenon in gas-solid fluidized bed coating process XXXIV Congresso Brasileiro de Sistemas Particulados, , Campinas, São Paulo, Brazil, October 18-21, 2009, (in Portuguese) Karimi, F., Sotudeh-Gharebagh, R., Zarghami, R., Mostoufi, N., Monitoring the moisture content of solids in fluidized bed dryers by analysis of pressure fluctuations (2011) Drying Technology, 29, pp. 1697-1704 Silva, C.A.M., Parise, M.R., Silva, F.V., Taranto, O.P., On-line control of fluidized bed wetting process XVII Congresso Brasileiro de Engenharia Química, , Foz do Iguaçu, Paraná, Brazil, September 19-22, 2010 (in Portuguese) Polastri, P.R., Silva, C.A.M., Taranto, O.P., On-line monitoring of fluidization regimes in coating process of diclofenac sodium pellets using Gaussian spectral analysis IX Congresso Brasileiro de Engenharia Química - Iniciação Científica, , Maringá, Paraná, Brazil, July 03-06, 2011 (in Portuguese) Watano, S., Sato, Y., Miyanami, K., Control of granule growth in fluidized bed granulation by an image processing system (1996) Chemical and Pharmaceutical Bulletin, 44 (8), pp. 1556-1560 Watano, S., Sato, Y., Miyanami, K., Optimization and validation of an image processing system in fluidized bed granulation (1997) Advanced Powder Technology, 8 (4), pp. 269-277 Watano, S., Numa, T., Miyanami, K., Osako, Y., On-line monitoring of granule growth in high shear granulation by an image processing system (2000) Chemical and Pharmaceutical Bulletin, 48 (8), pp. 1154-1159 Watano, S., Direct control of wet granulation processes by image processing system (2001) Powder Technology, 117 (1-2), pp. 163-172. , DOI 10.1016/S0032-5910(01)00322-9, PII S0032591001003229 Watano, S., Numa, T., Miyanami, K., Osako, Y., A fuzzy control system of high shear granulation using image processing (2001) Powder Technology, 115 (2), pp. 124-130. , DOI 10.1016/S0032-5910(00)00332-6, PII S0032591000003326 Frake, P., Greenhalgh, D., Grierson, S.M., Hempenstall, J.M., Rudd, D.R., Process control and end-point determination of a fluid bed granulation by application of near infra-red spectroscopy (1997) International Journal of Pharmaceutics, 151 (1), pp. 75-80. , DOI 10.1016/S0378-5173(97)04894-1, PII S0378517397048941 Goebel, S.G., Steffens, K.J., Online-measurement of moisture and particle size in the fluidized-bed processing with the near-infrared spectroscopy (1998) Pharmazeutische Industrie, 60, pp. 889-895 Findlay, W.P., Peck, G.R., Morris, K.R., Determination of fluidized bed granulation end point using near-infrared spectroscopy and phenomenological analysis (2005) Journal of Pharmaceutical Sciences, 94 (3), pp. 604-612. , DOI 10.1002/jps.20276 Tok, A., Goh, X.P., Ng, W., Tan, R., Monitoring granulation rate processes using three PAT tools in a pilot-scale fluidized bed (2008) AAPS PharmSciTech, 9, pp. 1083-1091 Scheibli, D., (2007) The Use of FBRM for On-line Particle Size Analysis in A Fluid Bed Granulator, , http://scholarworks.sjsu.edu/etd_theses/3576, Master's Theses. Paper 3576 Hu, X., Cunningham, J.C., Winstead, D., Study growth kinetics in fluidized bed granulation with at-line FBRM (2008) International Journal of Pharmaceutics, 347 (1-2), pp. 54-61. , DOI 10.1016/j.ijpharm.2007.06.043, PII S0378517307005261 Petrak, D., Simultaneous measurement of particle size and particle velocity by the spatial filtering technique (2002) Particle & Particle Systems Characterization, 19, pp. 391-400 Schmidt-Lehr, S., Moritz, H.U., Jürgens, K.C., Online control of particle size during fluidized bed granulation (2007) Pharmazeutische Industrie, 69, pp. 478-484 Närvänen, T., Lipsanen, T., Antikainen, O., Räikkönen, H., Yliruusi, J., Controlling granule size by granulation liquid feed pulsing (2008) International Journal of Pharmaceutics, 357, pp. 132-138 Ehlers, H., Liu, A., Räikkönena, H., Hataraa, J., Antikainena, O., Airaksinena, S., Heinämäkia, J., Yliruusi, J., Granule size control and targeting in pulsed spray fluid bed granulation (2009) International Journal of Pharmaceutics, 377, pp. 9-15 Närvänen, T., Lipsanen, T., Antikainen, O., Räikkönen, H., Heinämäki, J., Yliruusi, J., Gaining fluid bed process understanding by in-line particle size analysis (2009) Journal of Pharmaceutical Sciences, 98, pp. 1110-1117 Burggraeve, A., Van Den Kerkhof, T., Hellings, M., Remon, J.P., Vervaet, C., De Beer, T., Evaluation of in-line spatial filter velocimetry as PAT monitoring tool for particle growth during fluid bed granulation (2010) European Journal of Pharmaceutics and Biopharmaceutics, 76, pp. 138-146 Huang, J., Goolcharran, C., Utz, J., Hernandez-Abad, P., Ghosh, K., Nagi, A., A PAT Approach to enhance process understanding of fluid bed granulation using in-line particle size characterization and multivariate analysis (2010) Journal Pharmaceutical Innovation, 5, pp. 58-68 Dieter, P., Stefan, D., Günter, E., Michael, K., In-line particle sizing for real-time process control by fibre-optical spatial filtering technique (SFT) (2011) Advanced Powder Technology, 22, pp. 203-208 Watano, S., Miyanami, K., Image processing for on-line monitoring of granule size distribution and shape in fluidized bed granulation (1995) Powder Technology, 83, pp. 55-60 Watano, S., Takashima, H., Miyanami, K., Scale-up of agitation fluidized bed granulation by neural network (1997) Chemical and Pharmaceutical Bulletin, 45 (7), pp. 1193-1197 Nieuwmeyer, F.J.S., Damen, M., Gerich, A., Rusmini, F., Van Der, K., Maarschalk, V., Vromans, H., Granule characterization during fluid bed drying by development of a near infrared method to determine water content and median granule size (2007) Pharmaceutical Research, 24 (10), pp. 1854-1861. , DOI 10.1007/s11095-007-9305-5 Watano, S., Harada, T., Terashita, K., Miyanami, K., Development and application of moisture control system with IR moisture sensor to aqueous polymeric coating process (1993) Chemical and Pharmaceutical Bulletin, 41 (3), pp. 580-585 Bogomolov, A., Engler, M., Melichar, M., Wigmore, A., In-line analysis of a fluid bed pellet coating process using a combination of near infrared and Raman spectroscopy (2010) Journal of Chemometrics, 24, pp. 544-557 Watano, S., Sato, Y., Miyanami, K., Application of fuzzy logic to moisture control in fluidized bed granulation (1996) International Journal of Multiphase Flow, 22. , 125-125 Evett, S.R., Soil water measurement by time domain reflectometry (2003) Encyclopedia of Water Science, pp. 894-898. , Stewart, T.A. Howell, (Eds.) New York Starr, J.L., Paltineanu, I.C., Soil water measurement by capacitance (2003) Encyclopedia of Water Science, pp. 885-888. , Stewart, T.A. Howell, (Eds.) New York Gawande, N.A., Reinhart, D.R., Thomas, P.A., McCreanor, P.T., Townsend, T.G., Municipal solid waste in situ moisture content measurement using an electrical resistance sensor (2003) Waste Management, 23 (7), pp. 667-674. , DOI 10.1016/S0956-053X(03)00100-4 Watano, S., Terashita, K., Miyanami, K., Development and application of infrared moisture sensor to complex granulation (1990) Bulletin of University of Osaka Prefecture. Series A, 39, pp. 187-197 Watano, S., Terashita, K., Miyanami, K., Determination of end-point with a complex granulation applying infrared moisture sensor (1991) Chemical and Pharmaceutical Bulletin, 39, pp. 1013-1017 Watano, S., Yamamoto, A., Miyanami, K., Effects of operational variables on the properties of granules prepared by moisture control method in tumbling fluidized bed granulation (1994) Chemical and Pharmaceutical Bulletin, 42 (1), pp. 133-137 Watano, S., Fukushima, T., Miyanami, K., Murakami, T., Sato, T., Automation of the manufacturing process of cold remedy granules by a tumbling fluidized bed applying the fuzzy control method (1994) Chemical and Pharmaceutical Bulletin, 42 (6), pp. 1302-1307 Watano, S., Fukushima, T., Miyanami, K., Application of fuzzy logic to bed height control in agitation-fluidized bed granulation (1994) Powder Technology, 81 (2), pp. 161-168. , DOI 10.1016/0032-5910(94)02880-X Watano, S., Sato, Y., Miyanami, K., Control of moisture content by adaptive fuzzy control in agitation fluidized bed granulation (1995) Advanced and Powder Technology, 6, pp. 191-199 Watano, S., Takashima, H., Sato, Y., Yasutomo, T., Miyanami, K., Measurement of moisture content by IR sensor in fluidized bed granulation. Effects of operating variables on the relationship between granule moisture content and absorbance of IR spectra (1996) Chemical and Pharmaceutical Bulletin, 44 (6), pp. 1267-1269 Watano, S., Takashima, H., Sato, Y., Miyanami, K., Yasutomo, T., IR absorption characteristics of an IR moisture sensor and mechanism of water transfer in fluidized bed granulation (1996) Advanced Powder Technology, 7 (4), pp. 279-289 Watano, S., Takashima, H., Miyanami, K., Control of moisture content in fluidized bed granulation by neural network (1997) Journal of Chemical Engineering of Japan, 30, pp. 223-229 Rantanen, J., Jorgensen, A., Räsänen, E., Luukonene, P., Airaksinen, S., Raiman, J., Hänninen, K., Yliruusi, J., Process analysis of fluidized bed granulation (2001) AAPS PharmSciTech, 2. , (article 21) Mattes, R.A., Root, D.E., Birkmire, A.P., (2005) Inline Process Analysis of Residual Moisture in A Fluid Bed Granulator-Dryer Using NIR Spectroscopy, , Reprinted from SPECTROSCOPY, Advanstar Communications Inc Àlcala, M., Blanco, M., Bautista, M., González, J.M., On-line monitoring of a granulation process by NIR spectroscopy (2010) Journal of Pharmaceutical Sciences, 99, pp. 336-345 Watano, S., Online monitoring (2007) Handbook of Powder Technology, pp. 478-498. , A.D. Salman, M.J. Hounslow, J.P.K. Seville, (Eds.) Lourenço, V., Herdling, T., Reich, G., Menezes, J.C., Lochmann, D., Combining microwave resonance technology to multivariate data analysis as a novel PAT tool to improve process understanding in fluid bed granulation (2011) European Journal of Pharmaceutics and Biopharmaceutics, 78, pp. 513-521 Glatt GmbH, Method for monitoring and/or controlling and regulating a granulation, agglomeration, instantization, coating and drying process in a fluidized layer or a fluidized bed by determining product moisture, and device for carrying out said method, EP 0970369B1, 1997Reich, G., Near-infrared spectroscopy and imaging: Basic principles and pharmaceutical applications (2005) Advanced Drug Delivery Reviews, 57 (8), pp. 1109-1143. , DOI 10.1016/j.addr.2005.01.020, PII S0169409X05000578, Non-Invasive Spectroscopic and Imagign Techniques in Drug Delivery Roggo, Y., Chalus, P., Maurer, L., Lema-Martinez, C., Edmond, A., Jent, N., A review of near infrared spectroscopy and chemometrics in pharmaceutical technologies (2007) Journal of Pharmaceutical and Biomedical Analysis, 44 (3 SPEC. ISS.), pp. 683-700. , DOI 10.1016/j.jpba.2007.03.023, PII S0731708507001884 Green, R.L., Thurau, G., Pixley, N.C., Mateos, A., Reed, R.A., Higgins, J.P., In-line monitoring of moisture content in fluid bed dryers using near-IR spectroscopy with consideration of sampling effects on method accuracy (2005) Analytical Chemistry, 77 (14), pp. 4515-4522. , DOI 10.1021/ac050272q Kinsler, L.E., Frey, A.R., Coppens, A.B., Sanders, J.V., (2000) Fundamentals of Acoustics, , forth ed. John Wiley & Sons New York Boyd, J.W.R., Varley, J., The uses of passive measurement of acoustic emissions from chemical engineering processes (2001) Chemical Engineering Science, 56 (5), pp. 1749-1767. , DOI 10.1016/S0009-2509(00)00540-6, PII S0009250900005406 Tsujimoto, H., Yokoyama, T., Huang, C.C., Sekiguchi, I., Monitoring particle fluidization in a fluidized bed granulator with an acoustic emission sensor (2000) Powder Technology, 113, pp. 88-96 Briens, L., Bojarra, M., Monitoring fluidized bed drying of pharmaceutical granule (2010) AAPS PharmSciTech, 11, pp. 1612-1618 Matero, S., Poutiainen, S., Leskinen, J., Järvinen, K., Ketolainen, J., Reinikainen, S.P., Hakulinen, M., Poso, A., The feasibility of using acoustic emissions for monitoring of fluidized bed granulation (2009) Chemometrics and Intelligent Laboratory Systems, 97, pp. 75-81 Book, G., Albion, K., Briens, L., Briens, C., Berruti, F., On-line detection of bed fluidity in gas-solid fluidized beds with liquid injection by passive acoustic and vibrometric methods (2011) Powder Technology, 205, pp. 126-136 Buschmuller, C., Wiedey, W., Doscher, C., Dressler, J., Breitkreutz, J., In-line monitoring of granule moisture in fluidized-bed dryers using microwave resonance technology (2008) European Journal of Pharmaceutics and Biopharmaceutics, 69 (1), pp. 380-387. , DOI 10.1016/j.ejpb.2007.09.014, PII S0939641107003256 Dyakowski, T., Jeanmeure, L.F.C., Jaworski, A.J., Applications of electrical tomography for gas-solids and liquid-solids flows - A review (2000) Powder Technology, 112 (3), pp. 174-192. , DOI 10.1016/S0032-5910(00)00292-8, PII S0032591000002928 Chaplin, G., Pugsley, T., Application of electrical capacitance tomography to the fluidized bed drying of pharmaceutical granule (2005) Chemical Engineering Science, 60 (24), pp. 7022-7033. , DOI 10.1016/j.ces.2005.06.029, PII S0009250905005749 Wang, H.G., Senior, P.R., Mann, R., Yang, W.Q., Online measurement and control of solids moisture in fluidized bed dryers (2009) Chemical Engineering Science, 64, pp. 2893-2902