Artículos de revistas
Heck-matsuda Arylation As A Strategy To Access Kavalactones Isolated From Polygala Sabulosa, Piper Methysticum, And Analogues
Registro en:
European Journal Of Organic Chemistry. , v. , n. 19, p. 3607 - 3616, 2012.
1434193X
10.1002/ejoc.201200308
2-s2.0-84862742692
Autor
Soldi C.
Moro A.V.
Pizzolatti M.G.
Correia C.R.D.
Institución
Resumen
Herein, we describe the total syntheses of three bioactive pyrones isolated from Polygala sabulosa (i.e., 1, 4, and 7) and eight isolated from Piper methysticum (i.e., 8-10, 13, 15, and 18-20) using the Heck-Matsuda arylation as the key strategy. The evaluation of this methodology by employing different arenediazonium tetrafluoroborates revealed that the Heck arylation was more efficient when the olefin undergoing arylation possessed the vinyl-2-pyrone structural unit instead of the vinyl dihydro-2-pyrone moiety. The Heck-Matsuda arylation of many of the examined olefins proceeded in a practical manner with total regio- and stereocontrol. © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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