Artículos de revistas
Comparative Analysis Of Thalamic And Hippocampal Volume In Patients With Mesial Temporal Lobe Epilepsy Responsive Or Not To Drug Therapy [análise Comparativa Do Volume Hipocampal E Talâmico Em Pacientes Com Epilepsia De Lobo Temporal Mesial Com E Sem Resposta Adequada Ao Tratamento Farmacológico]
Registro en:
Journal Of Epilepsy And Clinical Neurophysiology. , v. 18, n. 2, p. 41 - 44, 2012.
16762649
10.1590/S1676-26492012000200004
2-s2.0-84872587295
Autor
Leoni T.B.
Coan A.C.
Cendes F.
Institución
Resumen
Objective: To investigate the variation of thalamic and hippocampal volume in patients with mesial temporal lobe epilepsy (MTLE) refractory or responsive to drug therapy. Methods: We analyzed 26 patients with MTLE responsive to drug therapy, 25 refractory and 23 controls through the manual delineation of anatomic limits of the hippocampus and thalamus, in sequential sections of MR images. The DISPLAY software was used. Statistical analysis was performed using the program Systat 9. Results: There were statistically significant differences between controls and patients groups for thalamic volumes ipsilateral to epileptogenic focus (p=0.00004). There was no statistical difference between the 3 groups for the volumes of the thalamus contralateral to the epileptogenic focus. There was significant correlation between ipsilateral hippocampus and thalamus ipsilateral to epileptogenic focus (r=0.35, p=0.004). The older the age, the lower the ipsilateral thalamic volume (p=0.002 and r=-0.37). Conclusion: The data showed that hippocampal atrophy is also present in patients with TLE and good seizure control. The atrophy of thalamus was correlated with the age of patients, which may also indicate that other factors besides the seizure frequency influences the degree of damage of this structure. 18 2 41 44 Babb, T.L., Brown, W.J., Pathological findings in epilepsy (1987) Surgical Treatment of the Epilepsies, pp. 511-540. , Engel Jr J (ed). New York: Raven Press Berkovic, S.F., Andermann, F., Olivier, A., Ethier, R., Melanson, D., Robitaille, Y., Hippocampal sclerosis in temporal lobe epilepsy demonstrated by magnetic resonance imaging (1991) Ann Neurol, 29, pp. 175-182 Jackson, G.D., Connelly, A., Duncan, J.S., Grünewald, R.A., Gadian, D.G., Detection of hippocampal pathology in intractable partial epilepsy: Increased sensitivity with quantitative magnetic resonance T2 relaxometry (1993) Neurology, 43, pp. 1793-1799 Dreifuss, S., VIngerhoets, F.J., Lazeyras, F., Andino, S.G., Spinelli, L., Delavelle, J., Volumetric measurements of subcortical nuclei in patients with temporal lobe epilepsy (2001) Neurology, 57, pp. 1636-1641 Natsume, J., Bernasconi, N., Andermann, F., Bernasconi, A., MRI volumetry of the thalamus in temporal, extratemporal, and idiopathic generalized epilepsy (2003) Neurology, 60, pp. 1296-1300 Keller, S.S., Mackay, C.E., Barrick, T.R., Wieshmann, U.C., Howard, M.A., Roberts, N., Voxel based mophometriccomparason of hippocampal and extrahippocampal abnormalities in patients with left and right hippocampal atrophy (2002) NeuroImage, 16, pp. 23-31 Andermann, F., Why study mesial temporal atrophy in patients with intractable temporal lobe epilepsy (2003) J Neurol Neurosurg Psychiatry, 74, pp. 1606-1607 Bonilha, L., Kobayashi, E., Cendes, F., Li, L.M., Rorden, C., Medial temporal lobe atrophy in patients with refractory lobe epilepsy (2003) J Neurol Neurosurg Psychiatry, 74, pp. 1627-1630 Durvenoy, H.M., Guyot, J., (1991) The Human Brain, , New York: Springer-Verlag Wien Robert, M., Gale, K., Gale, C., Mediodorsal Thalamus Plays a Critical Rolein the Development of Limbic Motor Seizures (1998) The Journal of Neuroscience, 21, pp. 9002-9009 Bonilha, L., Rorden, C., Castellano, G., Cendes, F., Li, L.M., Voxel-based morphometry of tha thalamus in patients with refractory medial temporal epilepsy (2005) NeuroImage, 25, pp. 1016-1021 Mathern, G.W., Adelson, P.D., Cahan, L.D., Leite, J.P., Hippocampal neuron damage in human epilepsy: Meyer's hypothesis revisited (2002) Prog Brain Res, 135, pp. 237-251 Proposal for revised classification of epilepsies and epileptic syndromes (1989) Epilepsia, 30 (4), pp. 389-399. , Commission on classification and terminology of the International League Against Epilepsy