Artículos de revistas
The Prevalence Of Iron Deficiency Anemia In Primary Antiphospholipid Syndrome [primer Antifosfolipid Sendromda Demir Eksikliǧi Anemisinin Prevalansi{dotless}]
Registro en:
Turkish Journal Of Rheumatology. , v. 28, n. 2, p. 96 - 100, 2013.
13090291
10.5606/tjr.2013.2717
2-s2.0-84879003525
Autor
Klack K.
Monma V.
Pelicari K.
Appenzeller S.
de Carvalho J.F.
Institución
Resumen
Objectives: The aim of this study was to evaluate the prevalence of subclinical and clinical iron deficiency with iron deficiency anemia in primary antiphospholipid syndrome (PAPS). Patients and methods: The study was comprised of 29 PAPS patients and 29 healthy controls matched for age, gender, and socioeconomic status. Participants received iron, folic acid, vitamin B12, and vitamin C. A battery of tests was performed to determine the iron storage. The mean disease duration was 70±51.3 months in the patient group. Results: Iron storage depletion was observed in 10.3% of the individuals in both groups (p=0.5). Iron deficient erythropoiesis (IDE) was observed in only three PAPS patients (10.3%) (p<0.001). Iron deficiency anemia (IDA) was more common in the PAPS patients compared to controls (48.2% vs. 10.3%, respectively; p=0.009). The mean iron levels were significantly lower in the PAPS group than the controls (75.5 vs. 95.8, respectively; p=0.03). Red cell distribution width-coefficient of variation (RDW-CV) (14.9 vs. 13.2; p=0.02) and red cell distribution widthstandard deviation (RDW-SD) (46.7 vs. 40.5; p=0.009) were significantly increased in the patient group. The folic acid and vitamin C levels were lower in the PAPS group than the control group (p<0.05). Conclusion: This study showed for the first time that PAPS patients have a higher incidence of IDA and IDE compared to healthy controls. This can be attributed to inadequate ingestion of folic acid and vitamin C. © 2013 Turkish League Against Rheumatism. All rights reserved. 28 2 96 100 Uthman, I., Godeau, B., Taher, A., Khamashta, M., The hematologic manifestations of the antiphospholipid syndrome (2008) Blood Rev, 22, pp. 187-194. , doi: 10.1016/j. blre.2008.03.005 Khamashta, M.A., Bertolaccini, M.L., Hughes, G.R., Antiphospholipid (Hughes) syndrome (2004) Autoimmunity, 37, pp. 309-312 Vermylen, J., Carreras, L.O., Arnout, J., Attempts to make sense of the antiphospholipid syndrome (2007) J Thromb Haemost, 5, pp. 1-4. , Epub 2006 Cook, J.D., Diagnosis and management of irondeficiency anaemia (2005) Best Pract Res Clin Haematol, 18, pp. 319-332 Tincani, A., Taraborelli, M., Cattaneo, R., Antiphospholipid antibodies and malignancies (2010) Autoimmun Rev, 9, pp. 200-202. , doi: 10.1016/j.autrev.2009.04.001 Miyakis, S., Lockshin, M.D., Atsumi, T., Branch, D.W., Brey, R.L., Cervera, R., International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS) (2006) J Thromb Haemost, 4, pp. 295-306 Miyakis, S., Lockshin, M.D., Atsumi, T., Branch, D.W., Brey, R.L., Cervera, R., International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS) (2006) J Thromb Haemost, 4, pp. 295-306 (1998) Dietary Reference Intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline., , http://www.nal.usda.gov/fnic/DRI//DRI_Thiamin/thiamin_full_report.pdf, National Agricultural Library. United States Departament of Agriculture. Food and Nutrition Information Center Available from (2000) Dietary Reference Intakes for vitamin C, vitamin E, selenium, and carotenoids., , http://www.nal.usda.gov/fnic/DRI/DRI_Vitamin_C/vitamin_c_full_report.pdf, National Agricultural Library. United States Departament of Agriculture. Food and Nutrition Information Center Available from (2001) Dietary Reference Intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc., , http://www.nal.usda.gov/fnic/DRI//DRI_Vitamin_A/vitamin_a_full_report.pdf, National Agricultural Library. United States Departament of Agriculture. Food and Nutrition Information Center Available from (2002) Departamento de Informática em Saúde., , Nutwin-Programa de Apoio à Nutrição. DIS-UNIFESP/EPM. Universidade Federal de São Paulo-Versão 1.5 Cook, J., The nutritional assessment of iron status (1999) Arch Latinoam Nutr, 49, pp. 11S-14S Pasricha, S.R., Flecknoe-Brown, S.C., Allen, K.J., Gibson, P.R., McMahon, L.P., Olynyk, J.K., Diagnosis and management of iron deficiency anaemia: A clinical update (2010) Med J Aust, 193, pp. 525-532 Killip, S., Bennett, J.M., Chambers, M.D., Iron deficiency anemia (2007) Am Fam Physician, 75, pp. 671-678 Cook, J.D., Diagnosis and management of iron-deficiency anaemia (2005) Best Pract Res Clin Haematol, 18, pp. 319-332