Artículos de revistas
Gastroprotective Effect Of The Ethanolic Extract And Fractions Obtained From Syngonanthus Bisulcatus Rul
Registro en:
Records Of Natural Products. , v. 7, n. 1, p. 35 - 44, 2013.
13076167
2-s2.0-84870387349
Autor
Batista L.M.
de Almeida A.B.A.
Lima G.R.M.
Falcao H.S.
Ferreira A.L.
Magri L.P.
Coelho R.G.
Calvo T.R.
Vilegas W.
Brito A.R.M.S.
Institución
Resumen
Syngonanthus bisulcatus Rul., popularly known in Brazil as "sempre-vivas chapadeira", is a plant of the family Eriocaulaceae, it is found in the states of Minas Gerais and Bahia. In this work, the ethanolic extract (EtOHE), flavonoid-rich (FRF), and flavonoid-deficient (FDF) fractions obtained from scapes of S. bisulcatus were investigated for gastroprotection in both rats and mice. The activity was evaluated in models for induced gastric ulcer (absolute ethanol, stress, non-steroidal anti-inflammatory drugs, and pylorus ligation). The participation of mucus and prostaglandin E2 were also investigated. Sb-EtOHE (50, 100, and 250 mg/kg, p.o.), Sb-FRF (100 mg/kg, p.o.), and Sb-FDF (100 mg/kg, p.o.) significantly reduced gastric injuries in all models. Sb-FRF altered gastric juice parameters after pylorus ligation. Sb-FRF and Sb-FDF (100 mg/kg each, p.o.) significantly increased the amount of adherent mucus in the gastric mucosa. Sb-FRF maintained the mucosal levels of prostaglandin after the administration of indomethacin. The results indicate that Sb-EtOHE, Sb-FRF and Sb-FDF have significant gastroprotective activity. 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