Artículos de revistas
Suramin Attenuates Dystrophin-deficient Cardiomyopathy In The Mdx Mouse Model Of Duchenne Muscular Dystrophy.
Muscle & Nerve. , v. 48, n. 6, p. 911 - 919, 2013.
De Oliveira Moreira D.
The purpose of this study was to determine the effects of suramin, an antifibrotic agent, on cardiac function and remodeling in mdx mice. mdx mice (8 months old) received intraperitoneal injections of suramin twice a week for 3 months. Control mdx mice (8 months old) were injected with saline. Suramin improved the electrocardiography profile with the main corrections seen in S- to R-wave ratio, PR interval, and Q amplitude, and a significant decrease in the cardiomyopathy index. Suramin decreased myocardial fibrosis, inflammation, and myonecrosis. These findings suggest that suramin may be a new adjunctive therapy to help improve cardiomyopathy in DMD. Copyright © 2013 Wiley Periodicals, Inc.486911919