Artículos de revistas
Epidemiological And Genetic Characteristics Associated With The Severity Of Acute Viral Bronchiolitis By Respiratory Syncytial Virus
Registro en:
Jornal De Pediatria. , v. 89, n. 6, p. 531 - 543, 2013.
217557
10.1016/j.jped.2013.02.022
2-s2.0-84887057566
Autor
Alvarez A.E.
De Lima Marson F.A.
Bertuzzo C.S.
Arns C.W.
Ribeiro J.D.
Institución
Resumen
Objective: to assess the epidemiological and genetic factors associated with severity of acute viral bronchiolitis (AVB) by respiratory syncytial virus (RSV). Data source: the key words "bronchiolitis", "risk factor", "genetics" and "respiratory syncytial virus", and all combinations among them were used to perform a search in the PubMed, SciELO, and Lilacs databases, of articles published after the year 2000 that included individuals younger than 2 years of age. Data synthesis: a total of 1,259 articles were found, and their respective summaries were read. Of these, 81 were selected, which assessed risk factors for the severity of AVB, and were read in full; the 60 most relevant studies were included. The epidemiologic factors associated with AVB severity by RSV were prematurity, passive smoking, young age, lack of breastfeeding, chronic lung disease, congenital heart disease, male gender, ethnicity, viral coinfection, low weight at admission, maternal smoking during pregnancy, atopic dermatitis, mechanical ventilation in the neonatal period, maternal history of atopy and/or asthma during pregnancy, season of birth, low socioeconomic status, Down syndrome, environmental pollution, living at an altitude > 2,500 meters above sea level, and cesarean section birth. Conversely, some children with severe AVB did not present any of these risk factors. In this regard, recent studies have verified the influence of genetic factors on the severity of AVB by RSV. Polymorphisms of the TLRs, RANTES, JUN, IFNA5, NOS2, CX3CR1, ILs, and VDR genes have been shown to be associated with more severe evolution of AVB by RSV. Conclusion: the severity of AVB by RSV is a phenomenon that depends on the varying degrees of interaction among epidemiological, environmental, and genetic variables. © 2013 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved. 89 6 531 543 Chávez-Bueno, S., Mejías, A., Welliver, R.C., Respiratory syncytial virus bronchiolitis: Current and future strategies for treatment and prophylaxis (2006) Treat Respir Med, 5, pp. 483-494 Ogra, P.L., Respiratory syncytial virus: The virus, the disease and the immune response (2004) Paediatr Respir Rev, 5, pp. 119-S126 Stockman, L.J., Curns, A.T., Anderson, L.J., Fischer-Langley, G., Respiratory syncytial virus-associated hospitalizations among infants and young children in the United States, 1997-2006 (2012) Pediatr Infect Dis J, 31, pp. 5-9 Leader, S., Kohlhase, K., Recent trends in severe respiratory syncytial virus (RSV) among US infants, 1997 to 2000 (2003) J Pediatr, 143, pp. 127-S132 Ranmuthugala, G., Brown, L., Lidbury, B.A., Respiratory syncytial virus - The unrecognised cause of health and economic burden among young children in Australia (2011) Commun Dis Intell, 35, pp. 177-184 Simões, E.A., Carbonell-Estrany, X., Impact of severe disease caused by respiratory syncytial virus in children living in developed countries (2003) Pediatr Infect Dis J, 22, pp. 13-S18. , discussion S18-20 Albernaz, E.P., Menezes, A.M., César, J.A., Victora, C.G., Barros, F.C., Halpern, R., Risk factors associated with hospitalization for bronchiolitis in the post-neonatal period (2003) Rev Saude Publica, 37, pp. 485-493 Deshpande, S.A., Northern, V., The clinical and health economic burden of respiratory syncytial virus disease among children under 2 years of age in a defined geographical area (2003) Arch Dis Child, 88, pp. 1065-1069 Fryzek, J.P., Martone, W.J., Groothuis, J.R., Trends in chronologic age and infant respiratory syncytial virus hospitalization: An 8-year cohort study (2011) Adv Ther, 28, pp. 195-201 Sung, C.C., Chi, H., Chiu, N.C., Huang, D.T., Weng, L.C., Wang, N.Y., Viral etiology of acute lower respiratory tract infections in hospitalized young children in Northern Taiwan (2011) J Microbiol Immunol Infect, 44, pp. 184-190 García, M.L., Ordobás Gabin, M., Calvo Reya, C., González Alvarez, M., Aguilar Ruiz, J., Arregui Sierra, A., Viral infection of the lower respiratory tract in hospitalized infants: Etiology, clinical features and risk factors (2001) An Esp Pediatr, 55, pp. 101-107 Riccetto, A.G., Ribeiro, J.D., Silva, M.T., Almeida, R.S., Arns, C.W., Baracat, E.C., Respiratory syncytial virus (RSV) in infants hospitalized for acute lower respiratory tract disease: Incidence and associated risks (2006) Braz J Infect Dis, 10, pp. 357-361 Salomão Junior, J.B., Gardinassi, L.G., Simas, P.V., Bittar, C.O., Souza, F.P., Rahal, P., Human respiratory syncytial virus in children hospitalized for acute lower respiratory infection (2011) J Pediatr (Rio J), 87, pp. 219-224 Sly, P.D., Jones, C.M., Viral co-detection in infants hospitalized with respiratory disease: Is it important to detect? (2011) J Pediatr (Rio J), 87, pp. 277-280 Miller, E.K., Williams, J.V., Gebretsadik, T., Carroll, K.N., Dupont, W.D., Mohamed, Y.A., Host and viral factors associated with severity of human rhinovirus-associated infant respiratory tract illness (2011) J Allergy Clin Immunol, 127, pp. 883-891 Nascimento, M.S., Souza, A.V., Ferreira, A.V., Rodrigues, J.C., Abramovici, S., Silva Filho, L.V., High rate of viral identification and coinfections in infants with acute bronchiolitis (2010) Clinics (Sao Paulo), 65, pp. 1133-1137 Groothuis, J.R., Fryzek, J.P., Makari, D., Steffey, D., Martone, W.J., Respiratory syncytial virus hospitalization trends in infants with chronic lung disease of infancy, 1998-2008 (2011) Clin Epidemiol, 3, pp. 245-250 Gouyon, J.B., Rozé, J.C., Guillermet-Fromentin, C., Glorieux, I., Adamon, L., Di Maio, M., Hospitalizations for respiratory syncytial virus bronchiolitis in preterm infants at < 33 weeks gestation without bronchopulmonary dysplasia: The CASTOR study (2012) Epidemiol Infect, 15, pp. 1-11 Semple, M.G., Taylor-Robinson, D.C., Lane, S., Smyth, R.L., Household tobacco smoke and admission weight predict severe bronchiolitis in infants independent of deprivation: Prospective cohort study (2011) PLoS One, 6, p. 22425 Koehoorn, M., Karr, C.J., Demers, P.A., Lencar, C., Tamburic, L., Brauer, M., Descriptive epidemiological features of bronchiolitis in a population-based cohort (2008) Pediatrics, 122, pp. 1196-1203 Ochoa Sangrador, C., González De Dios, J., Idoneidad y Adecuación). Consensus conference on acute bronchiolitis (VI): Prognosis of acute bronchiolitis. Review of scientific evidence (2010) An Pediatr (Barc), 72 (354), pp. e1-3634. , Grupo de Revisión del Proyecto aBREVIADo (BRonquiolitis-Estudio de Variabilidad Grimwood, K., Cohet, C., Rich, F.J., Cheng, S., Wood, C., Redshaw, N., Risk factors for respiratory syncytial virus bronchiolitis hospital admission in New Zealand (2008) Epidemiol Infect, 136, pp. 1333-1341 López Guinea, A., Casado Flores, J., Martín Sobrino, M.A., Espínola Docio, B., De La Calle Cabrera, T., Serrano, A., García Teresa, M.A., Severe bronchiolitis. Epidemiology and clinical course of 284 patients (2007) An Pediatr (Barc), 67, pp. 116-122 Chan, P.W., Lok, F.Y., Khatijah, S.B., Risk factors for hypoxemia and respiratory failure in respiratory syncytial virus bronchiolitis (2002) Southeast Asian J Trop Med Public Health, 33, pp. 806-810 Garcia, C.G., Bhore, R., Soriano-Fallas, A., Trost, M., Chason, R., Ramilo, O., Mejias, A., Risk factors in children hospitalized with RSV bronchiolitis versus non-RSV bronchiolitis (2010) Pediatrics, 126, pp. 1453-e1460 Chatzimichael, A., Tsalkidis, A., Cassimos, D., Gardikis, S., Tripsianis, G., Deftereos, S., The role of breastfeeding and passive smoking on the development of severe bronchiolitis in infants (2007) Minerva Pediatr, 59, pp. 199-206 Jones, L.L., Hashim, A., McKeever, T., Cook, D.G., Britton, J., Leonardi-Bee, J., Parental and household smoking and the increased risk of bronchitis, bronchiolitis and other lower respiratory infections in infancy: Systematic review and meta-analysis (2011) Respir Res, 12, p. 5 Bradley, J.P., Bacharier, L.B., Bonfiglio, J., Schechtman, K.B., Strunk, R., Storch, G., Severity of respiratory syncytial virus bronchiolitis is affected by cigarette smoke exposure and atopy (2005) Pediatrics, 115, pp. 7-e14 Hervás, D., Reina, J., Yañez, A., Del Valle, J.M., Figuerola, J., Hervás, J.A., Epidemiology of hospitalization for acute bronchiolitis in children: Differences between RSV and non-RSV bronchiolitis (2012) Eur J Clin Microbiol Infect Dis, 31, pp. 1975-1981 Oñoro, G., Pérez Suárez, E., Iglesias Bouzas, M.I., Serrano, A., Martínez De Azagra, A., Severe bronchiolitis. Changes in epidemiology and respiratory support (2011) An Pediatr (Barc), 74, pp. 371-376 Damore, D., Mansbach, J.M., Clark, S., Ramundo, M., Camargo Jr., C.A., Prospective multicenter bronchiolitis study: Predicting intensive care unit admissions (2008) Acad Emerg Med, 15, pp. 887-894 Papoff, P., Moretti, C., Cangiano, G., Bonci, E., Roggini, M., Pierangeli, A., Incidence and predisposing factors for severe disease in previously healthy term infants experiencing their first episode of bronchiolitis (2011) Acta Paediatr, 100, pp. 17-e23 Vidaurreta, S.M., Marcone, D.N., Ellis, A., Ekstrom, J., Cukier, D., Videla, C., Acute viral respiratory infection in children under 5 years: Epidemiological study in two centers in Buenos Aires, Argentina (2011) Arch Argent Pediatr, 109, pp. 296-304 Dornelles, C.T., Piva, J.P., Marostica, P.J., Nutritional status, breastfeeding, and evolution of infants with acute viral bronchiolitis (2007) J Health Popul Nutr, 25, pp. 336-343 Al-Shehri, M.A., Sadeq, A., Quli, K., Bronchiolitis in Abha, Southwest Saudi Arabia: Viral etiology and predictors for hospital admission (2005) West Afr J Med, 24, pp. 299-304 Che, D., Nicolau, J., Bergounioux, J., Perez, T., Bitar, D., Bronchiolitis among infants under 1 year of age in France: Epidemiology and factors associated with mortality (2012) Arch Pediatr, 19, pp. 700-706 Fjaerli, H.O., Farstad, T., Bratlid, D., Hospitalisations for respiratory syncytial virus bronchiolitis in Akershus, Norway, 1993-2000: A population-based retrospective study (2004) BMC Pediatr, 4, p. 25 Meissner, H.C., Selected populations at increased risk from respiratory syncytial virus infection (2003) Pediatr Infect Dis J, 22, pp. 40-S45 Riccetto, A.G., Silva, L.H., Spilki, F.R., Morcillo, A.M., Arns, C.W., Baracat, E.C., Genotypes and clinical data of respiratory syncytial virus and metapneumovirus in Brazilian infants: A new perspective (2009) Braz J Infect Dis, 13, pp. 35-39 D'Elia, C., Siqueira, M.M., Portes, S.A., Sant'Anna, C.C., Respiratory syncytial virus - Associated lower respiratory tract infections in hospitalized infants (2005) Rev Soc Bras Med Trop, 38, pp. 7-10 Weigl, J.A., Puppe, W., Schmitt, H.J., Variables explaining the duration of hospitalization in children under two years of age admitted with acute airway infections: Does respiratory syncytial virus have a direct impact? (2004) Klin Padiatr, 216, pp. 7-15 Brand, H.K., De Groot, R., Galama, J.M., Brouwer, M.L., Teuwen, K., Hermans, P.W., Infection with multiple viruses is not associated with increased disease severity in children with bronchiolitis (2012) Pediatr Pulmonol, 47, pp. 393-400 De Paulis, M., Gilio, A.E., Ferraro, A.A., Ferronato, A.E., Do Sacramento, P.R., Botosso, V.F., Severity of viral coinfection in hospitalized infants with respiratory syncytial virus infection (2011) J Pediatr (Rio J), 87, pp. 307-313 Jartti, T., Söderlund-Venermo, M., Hedman, K., Ruuskanen, O., Mäkelä, M.J., New molecular virus detection methods and their clinical value in lower respiratory tract infections in children (2013) Paediatr Respir Rev, 14, pp. 38-45 Carroll, K.N., Gebretsadik, T., Griffin, M.R., Dupont, W.D., Mitchel, E.F., Wu, P., Maternal asthma and maternal smoking are associated with increased risk of bronchiolitis during infancy (2007) Pediatrics, 119, pp. 1104-1112 Bloemers, B.L., Van Furth, A.M., Weijerman, M.E., Gemke, R.J., Broers, C.J., Van Den Ende, K., Down syndrome: A novel risk factor for respiratory syncytial virus bronchiolitis - A prospective birth-cohort study (2007) Pediatrics, 120, pp. 1076-e1081 Karr, C., Lumley, T., Schreuder, A., Davis, R., Larson, T., Ritz, B., Effects of subchronic and chronic exposure to ambient air pollutants on infant bronchiolitis (2007) Am J Epidemiol, 165, pp. 553-560 Choudhuri, J.A., Ogden, L.G., Ruttenber, A.J., Thomas, D.S., Todd, J.K., Simoes, E.A., Effect of altitude on hospitalizations for respiratory syncytial virus infection (2006) Pediatrics, 117, pp. 349-356 Moore, H.C., De Klerk, N., Holt, P., Richmond, P.C., Lehmann, D., Hospitalisation for bronchiolitis in infants is more common after elective caesarean delivery (2012) Arch Dis Child, 97, pp. 410-414 Thomsen, S.F., Stensballe, L.G., Skytthe, A., Kyvic, K.O., Backer, V., Bisgaard, H., Increased concordance of severe respiratory syncytial virus infection in identical twins (2008) Pediatrics, 121, pp. 493-496 Tal, G., Mandelberg, A., Dalal, I., Cesar, K., Somekh, E., Tal, A., Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease (2004) J Infect Dis, 189, pp. 2057-2063 Douville, R.N., Lissitsyn, Y., Hirschfeld, A.F., Becker, A.B., Kozyrskyj, A.L., Liem, J., TLR4 Asp299Gly and Thr399Ile polymorphisms: No impact on human immune responsiveness to LPS or respiratory syncytial virus (2010) PLoS One, 5, p. 12087 Löfgren, J., Marttila, R., Renko, M., Rämet, M., Hallman, M., Toll-like receptor 4 Asp299Gly polymorphism in respiratory syncytial virus epidemics (2010) Pediatr Pulmonol, 45, pp. 687-692 Mandelberg, A., Tal, G., Naugolny, L., Cesar, K., Oron, A., Houri, S., Lipopolysaccharide hyporesponsiveness as a risk factor for intensive care unit hospitalization in infants with respiratory syncitial virus bronchiolitis (2006) Clin Exp Immunol, 144, pp. 48-52 Puthothu, B., Forster, J., Heinzmann, A., Krueger, M., TLR-4 and CD14 polymorphisms in respiratory syncytial virus associated disease (2006) Dis Markers, 22, pp. 303-308 Mailaparambil, B., Krueger, M., Heinze, J., Forster, J., Heinzmann, A., Polymorphisms of toll like receptors in the genetics of severe RSV associated diseases (2008) Dis Markers, 25, pp. 59-65 Amanatidou, V., Sourvinos, G., Apostolakis, S., Neonaki, P., Tsilimigaki, A., Krambovitis, E., RANTES promoter gene polymorphisms and susceptibility to severe respiratory syncytial virus-induced bronchiolitis (2008) Pediatr Infect Dis J, 27, pp. 38-42 Kresfelder, T.L., Janssen, R., Bont, L., Venter, M., Confirmation of an association between single nucleotide polymorphisms in the VDR gene with respiratory syncytial virus related disease in South African children (2011) J Med Virol, 83, pp. 1834-1840 Janssen, R., Bont, L., Siezen, C.L., Hodemaekers, H.M., Ermers, M.J., Doornbos, G., Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes (2007) J Infect Dis, 196, pp. 826-834 Amanatidou, V., Sourvinos, G., Apostolakis, S., Tsilimigaki, A., Spandidos, D.A., T280 M variation of the CX3C receptor gene is associated with increased risk for severe respiratory syncytial virus bronchiolitis (2006) Pediatr Infect Dis J, 25, pp. 410-414 Ampuero, S., Luchsinger, V., Tapia, L., Palomino, M.A., Larrañaga, C.E., SP-A1, SP-A2 and SP-D gene polymorphisms in severe acute respiratory syncytial infection in Chilean infants (2011) Infect Genet Evol, 11, pp. 1368-1377 Mulet, J.F., Rodríguez De Torres, B.O., Viral induced bronchiolitis and genetics (2010) An Pediatr (Barc), 73, pp. 159-161