Artículos de revistas
Qsar Based On Biological Microcalorimetry. Iii Interaction Of M-alcoxyphenols And P-hydroxybenzoates With Escherichia Coli [estudos De Qsar Baseados Em Dados De Atividade Biológica Obtidos Por Microcalorimetria. Iii Interaçåo De M-alcoxifenóis E P-hidroxibenzoatos De Alquila Com Escherichia Coli]
Registro en:
Quimica Nova. , v. 20, n. 2, p. 125 - 131, 1997.
1004042
2-s2.0-0008120049
Autor
Volpe P.L.O.
Montanari C.A.
Institución
Resumen
QSAR studies based on flow microcalorimetric bioassay data for interaction of homologous series of m-alkoxyphenols and p-hydroxybenzoates with E. coli cells were carried out applying factorial design. Results for both series showed a linear relationship between log(dose)max and log Po/w. Analysis of these data allows the identification of contributions toward the derived bioactivity from the parent structures (the molecule minus n-CH2 groups present in the side-chain) and the lipophilic groups, CH2. These results are discussed with respect to drug quantitative structure-relationship. 20 2 125 131 Beezer, A.E., (1980) Biological Microcalorimetry, , Academic Press, London Beezer, A.E., Volpe, P.L.O., Miles, R.J., Hunter, W.H., (1986) J. Chem. Soc., Faraday Trans I, 82, p. 2929 Beezer, A.E., Volpe, P.L.O., Gooch, C.A., Hunter, W.H., (1986) Analytical Proceedings, 23, p. 399 Volpe, P.L.O., (1987) Quím. Nova, 10, p. 122 Volpe, P.L.O., (1988) Quím. Nova, 11, p. 435 Montanari, C.A., Montanari, M.L.C., Beezer, A.E., Giesbrecht, A.M., (1993) Quím. Nova, 16, p. 133 Montanari, M.L.C., Sandall, J.P.B., Beezer, A.E., Montanari, C.A., (1992) Int. J. Pharm., 85, p. 199 Leo, A., Hansch, C., Elkins, D., (1971) Chem. Rev., 71, p. 525 Dearden, J.C., (1983) Quantitative Approaches to Drug Design, , Elsevier, Amsterdam Rogers, J.A., Davis, S.S., (1980) Biochim. Diophys. Acta., 598, p. 392 Free, S.M., Wilson, J.W., (1964) J. Med. Chem., 7, p. 395 Kubinyi, H., (1990) Comprehensive Medicinal Chemistry, Quantitative Drug Design, 4, p. 589. , Ed. Ramsden, C. A. Pergamon Press, Oxford Beezer, A.E., Hunter, W.H., Storey, D.E., (1980) J. Pharm. Pharmacol., 32, p. 815 Kirsop, B.E., Snell, J.J., (1984) Maintenance of Microorganisms, , Academic Press, New York Volpe, P.L.O., (1993) Quím. Nova., 16, p. 49 Beezer, A.E., Volpe, P.L.O., Gooch, C.A., Hunter, W.H., Miles, R.J., (1986) International Journal of Pharmaceutics, 29, p. 237 Pleiss, M.A., Unger, S.H., (1990) Comprehensive Medicinal Chemistry Quantitative Drug Design, 4, p. 56. , Ed. Ramsden, C. A., Pergamon Press, Oxford Pastor, M., Alvares-Builla, J., (1991) Quant. Struct.-Act. Rel., 10, p. 350 Dimicky, M., Huhtanen, C.N., (1979) Antimicrob. Agents Chemother, 15, p. 798 Beezer, A.E., Gooch, C.A., Hunter, W.H., Volpe, P.L.O., (1987) J. Pharm. Pharmacol, 39, p. 774 Hansch, C., (1977) Biological Activity and Chemical Structure, p. 47. , ed. J. A. Kevering Buisman, Elsevier Franke, R., (1984) Theoretical Drug Design Methods, p. 282. , Elsevier Hansch, C., Hoekman, D., Gao, H., (1966) Chem. Rev., 96, p. 1045 Hammett, L.P., (1935) Chem. Rev., 17, p. 125 (1970) Physical Organic Chemistry, 2nd, Ed., , McGraw Hill, New York Tute, M.S., (1990) Comprehensive Medicinal Chemistry, Quantitative Drug Design, 4. , Ed. Ramsden, C. A., Pergamon Press, Oxford