Artículos de revistas
Extranodal Nasal Nk/t-cell Lymphoma: A Rare Oral Presentation Andfasn,cd44andglut-1expression
Registro en:
Brazilian Dental Journal. , v. 24, n. 3, p. 284 - 288, 2013.
1036440
10.1590/0103-6440201302202
2-s2.0-84881493621
Autor
Pontes H.A.R.
Pontes F.S.C.
Silva B.S.F.
Fonseca F.P.
de Andrade B.A.B.
Rizo V.H.T.
Romanach M.J.
Leon J.E.
de Almeida O.P.
Institución
Resumen
Extranodal natural killer (NK)/T-cell lymphoma is an aggressive malignant tumor with distinctive clinicopathological features, characterized by vascular invasion and destruction, prominent necrosis, cytotoxic lymphocyte phenotype and a strong association with EpsteinBarr virus. Here is reported an extranodal nasal NK/T-cell lymphoma case, involving the maxillary sinus, floor of the orbit, and interestingly extending to the oral cavity through the alveolar bone and buccal mucosa, preserving the palate, leading to a primary misdiagnosis of aggressive periodontal disease. Moreover, this work investigated for the first time the immunohistochemical expression of fatty acid synthase (FASN) and glucose transporter 1 (GLUT-1) proteins in this neoplasia. FASN showed strong cytoplasmatic expression in the neoplastic cells, whereas GLUT-1 and CD44 were negative. These findings suggest that the expression of FASN and the loss of CD44 might be involved in the pathogenesis of the extranodal nasal NK/T-cell lymphoma, and that GLUT-1 may not participate in the survival adaptation of the tumor cells to the hypoxic environment. Further studies with larger series are required to confirm these initial results. 24 3 284 288 Meng, W., Zhou, Y., Zhang, H., Jiang, L., Wang, Z., Li, X., Nasal-type NK/Tcell lymphoma with palatal ulcer as the earliest clinical manifestation: A case report with literature review (2010) Pathol Oncol Res, 16, pp. 133-137 Paik, Y.S., Liess, B.D., Scheidt, T.D., Ingram, E.A., Zitsch, R.P., Extranodal nasal-type natural killer/T-cell lymphoma masquerading as recalcitrant sinusitis (2010) Head Neck, 32, pp. 268-273 Swerdlow, S.H., WHO Classification of tumours of haematopoietic and lymphoid tissues (2008) IARC, , Lyon Wang, Z.Y., Li, Y.X., Wang, H., Wang, W.H., Jin, J., Liu, Y.P., Unfavorable prognosis of elderly patients with early-stage extranodal nasal-type NK/T-cell lymphoma (2011) Ann Oncol, 22, pp. 390-396 Alò, P.L., Visca, P., Botti, C., Galati, G.M., Sebastiani, V., Andreano, T., Immunohistochemical expression of human erythrocyte glucose transporter and fatty acid synthase in infiltrating breast carcinomas and adjacent typical/atypical hyperplastic or normal breast tissue (2001) Am J Clin Pathol, 116, pp. 129-134 da Silva, S.D., Cunha, I.W., Nishimoto, I.N., Soares, F.A., Carraro, D.M., Kowalski, L.P., Clinicopathological significance of ubiquitin-specific protease 2a (USP2a), fatty acid synthase (FASN), and ErbB2 expression in oral squamous cell carcinomas (2009) Oral Oncol, 45, pp. e134-ee139 Demasi, A.P.D., Costa, A.F., Altemani, A., Furuse, C., Araújo, N.C., Araújo, V.C., Glucose transporter protein 1 expression in mucoepidermoid carcinoma of salivary gland: Correlation with grade of malignancy (2010) Int J Exp Path, 91, pp. 107-113 Tzankov, A., Pehrs, A.C., Zimpfer, A., Ascani, S., Lugli, A., Pileri, S., Prognostic significance of CD44 expression in diffuse large B cell lymphoma of activated and germinal centre B cell-like types:A tissue microarray analysis of 90 cases (2003) J Clin Pathol, 56, pp. 747-752 Eberth, S., Schneider, B., Rosenwald, A., Hartmann, E.M., Romani, J., Zaborski, M., Epigenetic regulation of CD44 in Hodgkin and non-Hodgkin lymphoma (2010) BMC Cancer, 10, pp. 517-531 Naor, D., Wallach-Dayan, S.B., Zahalka, M.A., Sionov, R.V., Involvement of CD44, a molecule with a thousand faces, in cancer dissemination (2008) Sem Cancer Biol, 18, pp. 260-267 Choi, Y.L., Park, J.H., Namkung, J.H., Lee, J.H., Yang, J.M., Lee, E.S., Extranodal NK/T-cell lymphoma with cutaneous involvement:'nasal'vs.'nasaltype'subgroups:a retrospective study of 18 patients (2009) Br J Dermatol, 160, pp. 333-337 Reinartz, S.M., Schot, L.J., Riedl, R.G., Oldenburger, F., Van den Brekel, M.W., Presentation of two cases of nasal type NK/T-cell lymphoma (2007) Eur Arch Otorhinolaryngol, 264, pp. 39-43 Kim, T.M., Heo, D.S., Extranodal NK/T-cell lymphoma, nasal type: New staging system and treatment strategies (2009) Cancer Sci, 100, pp. 2242-2248 Uddin, S., Hussain, A.R., Ahmed, M., Bu, R., Ahmed, S.O., Ajarim, D., Inhibition of fatty acid synthase suppresses c-Met receptor kinase and induces apoptosis in diffuse large B-cell lymphoma (2010) Mol Cancer Ther, 9, pp. 1244-1255 Ohba, S., Fujii, H., Ito, S., Fujimaki, M., Matsumoto, F., Furukawa, M., Overexpression of GLUT-1 in the invasion front is associated with depth of oral squamous cell carcinoma and prognosis (2010) J Oral Pathol Med, 39, pp. 74-78 Charrad, R.S., Gadhoum, Z., Qi, J., Glachant, A., Allouche, M., Jasmin, C., Effects of anti-CD44 monoclonal antibodies on differentiation and apoptosis of human myeloid leukemia cell lines (2002) Blood, 99, pp. 290-299 Lien, H.C., Lin, C.W., Huang, P.H., Chang, M.L., Hsu, S.M., Expression of cyclin-dependent kinase 6 (Cdk6) and frequent loss of CD44 in nasalnasopharyngeal NK/T-cell lymphomas: Comparison with CD56-negative peripheral T cell lymphomas (2000) Lab Invest, 80, pp. 893-900