Giant Keratocystic Odontogenic Tumor: Three Cases And Literature Review

dc.creatorGuimaraes A.C.
dc.creatorSantos M.D.C.F.
dc.creatorde Carvalho G.M.
dc.creatorChone C.T.
dc.creatorPfeilsticker L.N.
dc.date2013
dc.date2015-06-25T19:11:12Z
dc.date2015-11-26T15:08:41Z
dc.date2015-06-25T19:11:12Z
dc.date2015-11-26T15:08:41Z
dc.date.accessioned2018-03-28T22:19:03Z
dc.date.available2018-03-28T22:19:03Z
dc.identifier
dc.identifierIranian Journal Of Otorhinolaryngology. Mashhad University Of Medical Sciences, v. 25, n. 73, p. 245 - 251, 2013.
dc.identifier22517251
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84903998389&partnerID=40&md5=370f4cf83366fd52d8ae4090488e8113
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/88622
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/88622
dc.identifier2-s2.0-84903998389
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1257719
dc.descriptionIntroduction: A keratocystic odontogenic tumor is a benign intra-bone mass originating from dental lamina or its residue. It represents 2-11% of jaw cysts, and has a slow but aggressive growth. The evaluation of molecular characteristics, immunohistochemistry, and genetic expression currently have no established classification regarding the evolution and pathophysiologic pattern of these lesions. Case Report: This is a clinical retrospective study with a full analysis of patient history regarding physical evaluation, radiologic images, pathology results, and surgical resection. We performed a major literature review concerning current concepts relating to its biological characterization. Three cases of keratocystic odontogenic tumor were identified. Two of the cases were large, with aggressive behavior and significant bone destruction and recurrence, which had been overlooked for more than a decade. The third case had an early diagnosis, and the treatment led to full recovery and complete healing. Conclusion: The keratocystic odontogenic tumor is a benign lesion with slow growth, which lends itself to a more conservative treatment, even in cases of large lesions. A better understanding of these tumors, both at the biological and molecular level, could lead to guidelines for treatment and prognosis of such patients.
dc.description25
dc.description73
dc.description245
dc.description251
dc.descriptionMendes, R.A., Carvalho, J.F., Van der Waal, I., Biological pathways involved in the aggressive behavior of the keratocystic odontogenic tumor and possible implications for molecular oriented treatment - an overview (2010) Oral Oncol, 46 (1), pp. 19-24
dc.descriptionZhang, L., Sun, Z.J., Zhao, Y.F., Bian, Z., Fan, M.W., Chen, Z., Inhibition of SHH signaling pathway: molecular treatment strategy of odontogenic keratocyst (2006) Med Hypotheses, 67 (5), pp. 1242-1244
dc.descriptionSharif, F.N., Oliver, R., Sweet, C., Sharif, M.O., Interventions for the treatment of keratocystic odontogenic tumours (KCOT, odontogenic keratocysts (OKC)) (2010) Cochrane Database Syst Rev, 8 (9), pp. CD008464
dc.descriptionLi, T.J., The odontogenic keratocyst: a cyst, or a cystic neoplasm? (2011) J Dent Res, 90 (2), pp. 133-142
dc.descriptionMendes, R.A., Carvalho, J.F., Van der Waal, I., Characterization and management of the keratocystic odontogenic tumor in relation to its histopathological and biological features (2010) Oral Oncol, 46 (4), pp. 219-225
dc.descriptionAragaki, T., Michi, Y., Katsube, K., Uzawa, N., Okada, N., Akashi, T., Comprehensive keratin profiling reveals different histopathogenesis of keratocysticodontogenic tumor and orthokeratinized odontogenic cyst (2010) Hum Pathol, 41 (12), pp. 1718-1725
dc.descriptionKuroyanagi, N., Sakuma, H., Miyabe, S., Machida, J., Kaetsu, A., Yokoi, M., Prognostic factors for keratocystic odontogenic tumor (odontogenic keratocyst): analysis of clinico-pathologic and immunohistochemical findings in cysts treated by enucleation (2009) J Oral Pathol Med, 38 (4), pp. 386-392
dc.descriptionSembronio, S., Albiero, A.M., Zerman, N., Costa, F., Politi, M., Endoscopically assisted enucleation and curettage of large mandibular odontogenic keratocyst (2009) Oral Surg Oral Med Oral Pathol Oral RadiolEndod, 107 (2), pp. 193-196
dc.descriptionRuhin-Poncet, B., Picard, A., Martin-Duverneuil, N., Albertini, A.F., Goudot, P., Keratocysts (or keratocystic epithelial odontogenic tumors) (2011) Rev Stomatol Chir Maxillofac, 112 (2), pp. 87-92
dc.descriptionZhao, Y., Liu, B., Wang, S.P., Wang, Y.N., Computed densitometry of panoramic radiographs in evaluation of bone healing after enucleation of mandibular odontogenic keratocysts (2010) Chin J Dent Res, 13 (2), pp. 123-126
dc.descriptionIhanHren, N., Miljavec, M., Spontaneous bone healing of the large bone defects in the mandible (2008) Int J Oral Maxillofac Surg, 37 (12), pp. 1111-1116
dc.descriptionMadras, J., Lapointe, H., Keratocystic odontogenic tumour: reclassification of the odontogenic keratocyst from cyst to tumour (2008) J Can Dent Assoc, 74 (2), pp. 165-1165
dc.descriptionMorgan, T.A., Burton, C.C., Qian, F., A retrospective review of treatment of the odontogenic keratocyst (2005) J Oral Maxillofac Surg, 63 (5), pp. 635-639
dc.descriptionZecha, J.A., Mendes, R.A., Lindeboom, V.B., Van derderWaal, I., Recurrence rate of keratocystic odontogenic tumor after conservative surgical treatment without adjunctive therapies - A 35-year single institution experience (2010) Oral Oncol, 46 (10), pp. 740-742
dc.descriptionPitak-Arnnop, P., Chaine, A., Oprean, N., Dhanuthai, K., Bertrand, J.C., Bertolus, C., Management of odonto- genic keratocysts of the jaws: a ten-year experience with 120 consecutive lesions (2010) J Craniomaxillofac Surg, 38 (5), pp. 358-364
dc.descriptionAugust, M., Faquin, W.C., Troulis, M.J., Kaban, L.B., Dedifferentiation of odontogenic keratocyst epithelium after cyst decompression (2003) J Oral Maxillofac Surg, 61 (6), pp. 678-683
dc.descriptionBoyne, P.J., Hou, D., Moretta, C., Pritchard, T., The multifocal nature of odontogenic keratocysts (2005) J Calif Dent Assoc, 33 (12), pp. 961-965
dc.descriptionFalaki, F., Delavarian, Z., Salehinejad, J., Saghafi, S., Squamous cell carcinoma arising from an odontogenic keratocyst: a case report (2009) Med Oral Patol Oral Cir Bucal, 14 (4), pp. E171-E174
dc.languageen
dc.publisherMashhad University of Medical Sciences
dc.relationIranian Journal of Otorhinolaryngology
dc.rightsfechado
dc.sourceScopus
dc.titleGiant Keratocystic Odontogenic Tumor: Three Cases And Literature Review
dc.typeArtículos de revistas


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