Eulerian three-dimensional transient simulations have been conducted to study the hydrodynamics of three phase flow inside a slurry bubble column with intermediate and high concentration of solid particles. The present work evaluated the influence of interactions among phases, in the time-averaged numerical results. Predictions were compared with experimental data available in the literature. Analysis of drag models for the liquid-solid and gas-solid interactions plays an important role in the dynamic behavior of a gas-solid-liquid slurry bubble column. The CFD models simulated was capable to predict gas holdup and (gas velocity) x (gas holdup) profiles similarly to that found experimentally. Copyright © 2013, AIDIC Servizi S.r.l.32 15071512Deckwer, W.D., (1992) Bubble Columns Reactors, , John Wiley & Sons Ltd, Chichester, UKGarside, J., Al-Dibouni, M.R., Velocity-voidage relationship for fluidization and sedimentation in solidliquid systems (1977) Ind. Eng. Chem. Process Des. Dev., 16 (2), pp. 206-214Jia, X., Wen, J., Feng, W., Yuan, Q., Local hydrodynamics modeling of a gas-liquid-solid three-phase airlift loop reactor (2007) Ind. Eng. Chem. Res., 46, pp. 5210-5220Kantarci, N., Borak, F., Ulgen, K., Bubble column reactors (2005) Proc. Bioche, 40, pp. 2263-2283Krishna, R., Van Baten, J.M., Eulerian simulation strategy for scaling up a bubble column slurry reactor for fischer-tropsch synthesis (2004) Ind. and Eng. Chemistry Research, 43, pp. 4483-4493Sato, Y., Sekoguchi, K., Liquid velocity distribution in two-phase bubble flow (1975) International Journal of Multiphase Flow, 2, pp. 79-95Schallenberg, J., En, J.H., Hempel, D.C., The important role of local dispersed phase hold-ups for the calculation of three-phase bubble columns (2005) Chem. Eng. Science, 60, pp. 6027-6033Silva, M.K., D'ávila, M.A., Mori, M., Cfd modelling of a bubble column with a external loop in the heterogeneous regime (2011) Canadian Journal of Chemical Engineering, 89, pp. 671-681Syamlal, M., O'Brien, T.J., Computer simulation of bubbles in a fluidized bed (1989) AIChE Symp. Series, 85, pp. 22-31Tabib, M.V., Roy, S.A., Joshi, J.B., Cfd simulation of bubble column - an analysis of interphase forces and turbulence models (2008) Chemical Engineering Journal, 139, pp. 589-614Wu, C., Suddard, K., Al-Dahhan, M.H., Bubble dynamics investigation in a slurry bubble column (2008) AIChE Journal, 54, pp. 1203-1212