Actas de congresos
Cálculo De Elastância Em Curvas Pressão-volume Em Pulmões Lesados Por Paraquat: Modelo De Lesão Pulmonar Aguda
Registro en:
9783642211973
Ifmbe Proceedings. , v. 33 IFMBE, n. , p. 212 - 215, 2013.
16800737
10.1007/978-3-642-21198-0_54
2-s2.0-84875255485
Autor
Ferreira M.Z.J.
Silva T.H.G.
Silva M.F.R.
Alencar A.M.
Moriya H.T.
Hernandez-Figueroa H.E.
Institución
Resumen
Acute lung injury, whose most severe expression is Respiratory Distress Syndrome, was described 40 years ago. Despite all research in this field, mortality rate still remains around 35%. In this study we used a model of acute lung injury with paraquat, an herbicide that causes alveolar instability through destruction of surfactant, to obtain pressure-volume curves of lungs in open-chest rats. The objectives were to study acute lung injury through measurements of lung elastance during inspiratory and expiratory maneuvers. We observed a rise in elastance during the initial part of the inspiratory maneuver (0-5mL approx.) in animals exposed to paraquat possibly due to increased alveolar collapse. We suppose that alveolar recruitment is responsible for the absence of significant elastance changes in other phases of the inspiratory maneuver. © 2013 Springer. 33 IFMBE
212 215 SKAN AG,Materialise NV,Bavarian Minist. Econ., Aff., Infrastruct., Transp. Technol.,Bavarian Bureau for International Business Relations GmbH,AKUD - Med Pharm GmbH MacIntyre, N.R., Is there a best way to set positive expiratory-end pressure for mechanical ventilatory support in acute lung injury? (2008) Clin Chest Med, 29, pp. 233-239 Erickson, S.E., Martin, G.S., Davis, J.L., Mathay, M.A., Eisner, M.D., Recent trends in acute lung injury mortality: 1996-2005* (2009) Crit Care Med, 37, pp. 1574-1579. , MD MD, MSc MD MD MD, MPH for the NIH NHLBI ARDS Network Matute-Bello, G., Frevert, C.W., Martin, T.R., Animal models of acute lung injury J Physiol Lung Cell Mol Physiol, 295, pp. 379-399. , doi:10.1152/ajplung.00010.2008 Silva, M.F.R., Saldiva, P.H.N., Paraquat poisoning: An experimental model of dose-dependent acute lung injury due to surfactant dysfunction (1998) Brazilian Journal of Medical and Biological Research, 31 (3), pp. 445-450 Silva, M.F.R., Zin, W.A., Saldiva, P.H.N., Airspace configuration at different transpulmonary pressures in normal and paraquat-induced lung injury in rats (1998) American Journal of Respiratory and Critical Care Medicine, 158 (4), pp. 1230-1234