Artículos de revistas
Peri-infarct Zone Characterized By Cardiac Magnetic Resonance Imaging Is Directly Associated With The Inflammatory Activity During Acute Phase Myocardial Infarction
Registro en:
Inflammation. Springer New York Llc, v. 37, n. 3, p. 678 - 685, 2014.
3603997
10.1007/s10753-013-9784-y
2-s2.0-84902544073
Autor
Quinaglia E Silva J.C.
Coelho-Filho O.R.
Andrade J.M.
Quinaglia T.
Modolo R.G.P.
Almeida B.O.
Van Der Geest R.J.
Jerosch-Herold M.
Coelho O.R.
Sposito A.C.
Institución
Resumen
Enhanced systemic inflammatory activity (SIA) during myocardial infarction (MI) and the extent of the peri-infarct zone characterized by cardiac magnetic resonance imaging (CMRi) are both associated with increased risk of life-threatening arrhythmias and sudden cardiac death. The present study investigated the existence of association between these two phenomena in 98 patients (55±10 years) with ST segment elevation MI. Plasma levels of C-reactive protein (CRP), interleukin-2 (IL-2), and tumor necrosis factor (TNF) were measured on admission (D1) and on the fifth day post-MI (D5). CMRi was performed 2 weeks after MI to quantify peri-infarct zone (PIZ). Between D1 and D5, the increase in CRP (6.0 vs. 5.6 times; p=0.02), IL-2 (3.6 vs. 3.4 times; p=0.04) and tumor necrosis factor type α (TNF-α; 4.6 vs. 3.9 times; p=0.001) were higher in patients with PIZ above the median than in the counterparts. 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